Martin Pilhofer

This study identifies surface proteins in Asgard archaea using visual surfaceomics, revealing a peptidophilic cell surface involved in peptide capture and symbiotic interactions.

This study shows diatom spines capture and lyse bacteria, enabling nutrient acquisition and revealing a suspension-feeding strategy in phytoplankton.

The paper engineers an extracellular contractile injection system (PROCIS) for targeted delivery of proteins to mammalian and bacterial cells, identifying key components for cargo loading and delivery.

This study elucidates the stepwise firing mechanism of the Algoriphagus machipongonensis extracellular contractile injection system using cryo-EM and structure-guided engineering.

The paper identifies a novel contractile injection system in thermophilic bacteria from hot spring mats using cryoET and metagenomics.

This study identifies CisA as a membrane protein essential for the function of the Streptomyces coelicolor contractile injection system, showing it mediates recruitment to the membrane and firing.

This study identifies Stm1's role in promoting ribosome biogenesis by regulating Ifh1 activity, revealing a link between ribosome biogenesis and dormancy.

The paper identifies a contact-dependent antagonism mechanism in archaea mediated by a CIS similar to bacterial T6SSs, revealing its role in shaping microbial communities.

This study identifies the molecular mechanisms of ixotrophy in bacteria, revealing the role of multiple secretion systems and regulatory elements in predatory behavior.

The paper introduces FilamentID, a workflow to identify filament composition in cells, finding Ald4ALDH2 and Acs1ACSS2 form filaments in mitochondria and nucleus during meiosis, aiding cell recovery from stress.

This paper describes an automated method for preparing cryoET samples, reducing preparation time and user input while enabling high-quality lamellae for imaging and subtomogram averaging.