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Measuring satellite arrays of the human Y chromosome from sequencing reads

The paper introduces Yruler, a tool to measure Y chromosome satellite arrays from sequencing reads without alignment, revealing lineage-specific variations in satellite length and composition.

A reporter mouse model to map RIG-I expression and function in vivo

This paper develops a RIG-I reporter mouse model to track RIG-I expression and function in vivo, revealing its tissue distribution and identifying alveolar macrophages as key sensor cells.

Midlife nonlinearities across scale in Biondi body amyloid formation in the human choroid plexus

The paper examines age-related accumulation of Biondi bodies in human choroid plexus epithelial cells, finding nonlinear increases in prevalence and load, and suggesting prion-like spread mechanisms.

Transition Fibers Play a Central Role in Import of a Glucose Transporter into the Flagellar Membrane

This study identifies KHARON as a component of transition fibers that facilitate the transport of the glucose transporter GT1 into the flagellar membrane via interaction with IFT trains.

Unraveling Systemic Responses to NQO1-Activated IB-DNQand Rucaparib Single and Dual Agent Therapy in Triple-Negative Breast Cancers

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

LAP-TLR2 Axis Drives Inflammatory Pathology during Listeria monocytogenes Gastroenteritis

This study identifies LAP-TLR2 signaling as a key driver of inflammatory pathology in Listeria monocytogenes gastroenteritis, showing its role in epithelial damage and neutrophil recruitment.

A mammalian fibroblast zoo reveals barriers to cross-species virus replication and differential regulation of antiviral immunity

The paper uses fibroblasts from 86 mammalian species to study virus-host susceptibility and innate immune responses across diverse mammals.

Apparent sequential effects due to trial-to-trial fluctuations in decision criterion

This study shows that trial-to-trial fluctuations in decision criterion can explain sequential effects in decision making, challenging the assumption that these effects are caused by updates to decision parameters.

Compositional computations in the primate frontal cortex

The paper investigates how neural circuits in the primate frontal cortex support compositional generalization by separating computations into spatial and temporal components and identifying biases when these components are misaligned.

An unprecedented codon reassignment and two new genetic code variants in ciliates

The paper identifies new genetic code variants in ciliates, including an unprecedented codon reassignment in Licnophora and a previously unreported reassignment in Balantidium ctenopharyngodoni.

Next generation Human Neocortical Neurosolver model with biophysically realistic somatic, dendritic and synaptic dynamics

The paper updates the Human Neocortical Neurosolver model to include biophysically realistic dynamics in human neurons, enabling better interpretation of EEG/MEG signals.

Metatranscriptomic Profiling of Viral Diversity in Aquatic Environments with a Focus on Microalgal Viruses

The paper uses metatranscriptomics to analyze viral diversity in freshwater and marine environments, identifying new RNA viruses associated with microalgae and proposing a new genus within Marnaviridae.

RoDPAA: A Robust Dissimilarity-Based Principal Angle Analysis Framework for Multi-View Microbiome Data Integration

RoDPAA integrates multi-view microbiome data using dissimilarity-based principal angle analysis, recovering shared structure in IBD cohorts where log-ratio methods failed.

Prenatal THC exposure alters metabolic gene expression and KEAP1 regulation in the mouse placental labyrinth

This study shows prenatal THC exposure reduces metabolic gene expression and KEAP1 in mouse placental labyrinth, while CBD has no significant effect.

Extended Pavlovian conditioned approach training and devaluation in Long-Evans rats using time-restricted feeding

This study develops an extended Pavlovian conditioned approach paradigm in Long-Evans rats under time-restricted feeding to better identify phenotypes linked to compulsive behaviors and stress-related dysregulation.

Towards an analytical framework for investigating the neurophysiological influence of social context in speech perception

The paper introduces a framework combining a fine-tuned LLM and TRFs to isolate social context's influence on speech perception, showing social context improves EEG prediction.

Genomic evidence of a single domestication origin for modern cattle

The paper uses whole-genome analyses to challenge the two-domestication model of cattle, showing zebu originated from admixture between taurine cattle and Indian aurochs with introgression from gaur-like or banteng-like populations.

Joint protein-DNA language modeling enables prediction and engineering of DNA recognition specificity

This paper introduces PDLMs, protein-DNA language models that jointly represent protein and DNA sequences to predict and engineer DNA recognition specificity.

LeadWeaver: Topology-Aware Masked-Lead Modeling for Robust 12-Lead ECG Diagnosis

LeadWeaver improves ECG diagnosis by modeling lead topology and uncertainty, outperforming methods that treat missing leads as zero-valued inputs.

Predicting Transcriptional Responses to Unseen Compounds through Context Modeling and Multi-View Transfer

UnDetect improves transcriptional prediction of unseen compounds by separating context from compound effects and integrating multi-view data.