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This study shows that tFUS targeting the PCC during mindfulness training increases DMN-CEN decoupling in novices, mimicking effects seen in experienced meditators after just two weeks.

This study shows TMEM174 deficiency shortens lifespan by promoting phosphate-driven vascular calcification through its role in NPT2A regulation.

This study uses single-molecule FRET to show that gp41-directed antibodies stabilize or open the prefusion-closed state of HIV-1 Env, revealing two neutralization mechanisms.

This study identifies the TERRA-NONO axis as a driver of fibroblast reprogramming into cancer-associated fibroblasts, showing its therapeutic potential in multiple cancers.

This paper introduces a structure-aware generative framework that integrates geometric encoding and coevolutionary constraints to map, cluster, and design protein sequences, improving homology detection and structure-guided sequence generation.

This study identifies Tween 20 as a surfactant that enhances colorimetric glucose sensing on paper by preserving enzyme activity during drying, improving detection limits and signal stability.

This paper presents a computational framework for embedding wear estimation in musculoskeletal simulations, demonstrating its feasibility in total hip arthroplasty.

This study identifies sustained cell cycle activity as a mechanism of resistance to KRAS inhibitors and shows that co-targeting cell cycle nodes with CDK4/6 or CDK2 restores sensitivity and provides durable tumor control.

The paper investigates redox distribution of Asgard archaea and co-occurring taxa in microbial mats from an early Proterozoic ecosystem analog, revealing their ecological niches and potential roles in early eukaryogenesis.

This study identifies molecular pathways and regulatory programs associated with hPSC-CM maturation through multi-omic profiling during long-term culture.

This study determines how the I-F3 CRISPR-associated transposase recognizes and pairs transposon ends for transposition using cryo-EM and biochemical analyses.

The paper identifies lncRNA-miRNA-mRNA regulatory networks in neurodegenerative diseases using RNA-seq data and network analysis, revealing disease-specific and shared post-transcriptional modules.

This study investigates the functional roles of TANGO1S domains in maintaining ER-Golgi architecture by analyzing domain-deletion mutants in knockout cells.

The paper compares small and large extracellular vesicles from healthy pregnancies to identify subtype-specific cargo differences and establish a reference for normal EV biology.

LoGicAl estimates ancestry-specific allele frequencies from admixed samples by accounting for uncertainty in local ancestry and genotype calling, improving accuracy and scalability.

This study uses optical genome mapping to compare structural variant profiles of iPSCs derived from different somatic cell sources, finding differences in SV burden and types between PBMC- and fibroblast-derived clones.

PhyloZoo provides a Python framework for phylogenetic network analysis, supporting multiple representations and offering tools for visualization and I/O.

This study identifies the CCL20-CCR6 axis as a driver of chronic neuroinflammation after rTBI and shows that shRNA targeting this axis reduces synaptic loss and improves behavioral outcomes.

This study tracks rhizosphere microbiome assembly in tomato plants during early development, showing inoculum-constrained succession with increased phylogenetic clustering and diversity.