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The paper shows that a compact set of regulatory motifs can explain gene expression across diverse human cell types through context-dependent interpretation.

This study reports cryo-EM structures of human PAT-1 with inhibitors to elucidate their inhibition mechanisms and domain interactions.

This study develops tetrasulfide-incorporated mesoporous silica nanoparticles to enhance mRNA delivery by optimizing morphology and chemistry, showing improved cellular uptake and mRNA stability.

This study compares the antischistosomal effects of antimalarials and TRP agonists using RNA-seq and efficacy tests in mice, finding distinct transcriptional responses and retained activity against praziquantel-resistant parasites.

This study identifies CrJAM2 and CrJAM3 as transcriptional repressors of the MIA pathway in C. roseus, showing their repression is modulated by methyl JA treatment.

The paper identifies how three transcriptomic cell types in the superior colliculus process visual motion with distinct feature selectivity, morphology, and connectivity.

The paper identifies a supramodal brain network involved in perceptual decision formation and links it to the EEG centroparietal positivity (CPP) signal using fMRI and EEG data.

This study shows Apelin signaling regulates neuroendocrine homeostasis in zebrafish via Atoh8-dependent transcriptional control, affecting development, fertility, and aging.

The paper identifies Rab10 modulators through virtual screening and evaluates their effects on Alzheimer's disease-related cellular phenotypes.

This study investigates how partial agonists affect desensitization in KARs, showing that agonist residence time and LBD closure are more critical than subunit composition in heteromeric receptors.

This study identifies factors influencing Sleeping Beauty transposition, showing chromatin context, cargo size, and transcriptional activity affect efficiency and reintegration patterns.

This study shows that removing maternal compensation in zebrafish reveals retinal-specific roles for Pomgnt1, with retinal abnormalities appearing early and behavioral changes observed.

HLAResolver improves HLA resolution in T-cell response data by integrating MIRA responses with NetMHCpan predictions, achieving higher sensitivity and fewer candidate HLAs.

The paper investigates the mcm4Chaos3 mutation in yeast, showing it causes genome instability by impairing specific centromere-proximal origins.

The paper identifies a non-canonical helical binding motif in MAD1 that specifically interacts with Cyclin B1 to recruit CDK1 to the SAC, revealing a mechanism for B-type cyclin recognition.

The paper proposes a Bayesian model explaining how the circadian clock integrates light intensity and wavelength to estimate astronomical time despite natural variability.

The paper assesses the robustness of immune transcriptomic recovery after myocardial infarction by evaluating how missing data and assay availability affect inflammatory-response scores over time.

This paper develops a theoretical framework to analyze cardiac-autonomic regulation using dynamical systems theory and demonstrates its properties through simulations.

The paper identifies a HNRNPU-CHD2 RNA-processing axis linked to neurodevelopmental disease by showing HNRNPU depletion causes splicing changes in CHD2 that may lead to nonsense-mediated decay.