Z. Peng

Follow-up availability and the robustness of immune transcriptomic recovery after myocardial infarction

The paper assesses the robustness of immune transcriptomic recovery after myocardial infarction by evaluating how missing data and assay availability affect inflammatory-response scores over time.

Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response

This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.

Late-Life Alcohol Exposure Does Not Exacerbate Age-Dependent Reductions in Mouse Spatial Memory and Brain TFEB Activity

This study examines the effects of late-life alcohol exposure on spatial memory and TFEB activity in young and aged mice, finding that aging has a greater impact than alcohol.

Genome analysis and hyphal movement characterization of the hitchhiker endohyphal Enterobacter sp. from Rhizoctonia solani

This study characterizes the genome of an endohyphal Enterobacter sp. and describes its hyphal movement and potential ecological impact on fungal hosts.

Microstructure-based Nuclear Lamina Constitutive Model

This paper develops a microstructure-based constitutive model of the nuclear lamina to simulate its mechanical behavior and impact on nuclear transmigration.

Microstructure-Based Modeling of Primary Cilia Mechanics

This paper develops a microstructure-based model of primary cilia, distinguishing structural and sensing components, and finds that membrane curvature, not stretching, may activate transmembrane proteins.

A chromosome-scale and haplotype-resolved genome assembly of tetraploid blackberry (Rubus L. subgenus Rubus Watson)

This paper presents a chromosome-scale, haplotype-resolved genome assembly for tetraploid blackberry, identifying candidate genes related to thornlessness and fruiting habit.

Development of a xylose-inducible promoter and riboswitch combination system for manipulating gene expression in Fusobacterium nucleatum

This paper develops a leakage-free gene expression system in Fusobacterium nucleatum by combining a xylose-inducible promoter with a theophylline-responsive riboswitch, demonstrating precise control of gene expression and identifying essential genes.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

Physical mechanisms of red blood cell splenic filtration

This paper investigates how red blood cells pass through narrow splenic slits using multiscale modeling, live imaging, and microfluidic experiments, finding that cells deform into two tether-connected spheres and unfold their cytoskeleton to pass through.

A pilot study of stable isotope fractionation in Bombyx mori rearing

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

This study shows that reduced GCN5L1 expression in the failing heart leads to mitochondrial dysfunction and decreased bioenergetic output.

Vascular endothelial growth factor A contributes to the increasing of mammalian respiratory epithelial permeability induced by Pasteurella multocida infection

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

Transfer Entropy Based Causality from Head Motion to Eye Movement for Visual Scanning in Virtual Driving

This paper quantifies causality from head motion to eye movement using transfer entropy to assess driving performance in virtual reality.

Myoglobin promotes cardiomyocyte differentiation through oxidatively modulating the Hippo Kinase Pathway

This study shows myoglobin promotes cardiomyocyte differentiation by modulating the Hippo pathway through oxidative regulation of LATS1 and YAP.

SMC1A facilitates gastric cancer cells proliferation, migration and invasion via promoting SNAI2 activated EMT

This study shows SMC1A promotes gastric cancer progression by enhancing SNAI2-driven EMT, suggesting it as a therapeutic target.

Cyclic mechanical stresses alter erythrocyte membrane composition and microstructure and trigger macrophage phagocytosis

This study shows cyclic mechanical stress alters erythrocyte membrane composition and microstructure, leading to increased macrophage phagocytosis.

A temperate Siphoviridae bacteriophage isolate from Siberian tiger enhances the virulence of Methicillin-resistant Staphylococcus aureus through distinct mechanisms

This study isolates a temperate Siphoviridae bacteriophage from a Siberian tiger that enhances MRSA virulence through gene upregulation without carrying virulence or resistance genes.

Population genomics of Salmonella enterica serovar Weltevreden ST365, an emerging predominant causative agent of diarrheal disease

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

Autophagy Induced by Palmitic Acid: a Brake in NAFLD Neutrophils

This paper shows that palmitic acid induces autophagy in NAFLD neutrophils, leading to granule degradation and reduced adhesion, impairing neutrophil function.

High-resolution single-molecule long-fragment rRNA gene amplicon sequencing for uncultured bacterial and fungal communities

This study develops a method to sequence nearly full-length rRNA genes from environmental samples, achieving high accuracy and coverage in microbial community analysis.

Bacterium-Enabled Transient Gene Activation by Artificial Transcription Factor for Resolving Gene Regulation in Maize

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

Mycobacteria tuberculosis PPE36 modulates host inflammation by promoting E3 ligase Smurf1-mediated MyD88 degradation

This study identifies PPE36 as a Mycobacterium tuberculosis protein that modulates host inflammation by promoting Smurf1-mediated MyD88 degradation, enhancing bacterial survival.

Rv3737 is required for Mycobacterium tuberculosis growth in vitro and in vivo and correlates with bacterial load and disease severity in human tuberculosis

Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China

The paper models the 2019-nCov epidemic in China, finding comparable transmissibility but lower fatality rates than SARS and MERS, and highlights the impact of early interventions.

MiRNA-223 Inhibits MouseGallstone Formation by Targeting Key Transporters in Hepatobiliary Cholesterol Secretion Pathway

This study shows that miRNA-223 inhibits gallstone formation in mice by targeting ABCG5 and ABCG8, key transporters in the bile cholesterol secretion pathway.

Expansion Revealing: Decrowding Proteins to Unmask Invisible Brain Nanostructures

Expansion Revealing decrowds proteins to reveal previously invisible nanostructures in brain tissue, including presynaptic calcium channel alignment and amyloid nanoclusters in Alzheimer's models.

Chronic Exposure to Palmitic Acid Downregulates AKT in Beta-Cells through Activation of mTOR

This study shows chronic palmitic acid exposure reduces AKT in beta-cells via mTOR activation, leading to cell cycle inhibition and T2D risk.