Author
Gamma Chi
University of OxfordORCID 0000-0001-9910-0965Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 14 mutual co-author links5 papers
Recent·Most cited
- Systems BiologyMolecular Systems BiologyPeer-reviewed
Metabolic mapping of the human solute carrier superfamily
Tabea Wiedmer, Shao Thing Teoh, Eirini Christodoulaki…·Giulio Superti‐Furga
The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.
20 citationstop 2% - Molecular BiologyNature CommunicationsPeer-reviewed
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment
Zhuoyao Chen, Gamma Chi, Timea Baló…·Alex N. Bullock
The paper identifies how neomorphic KBTBD4 mutations and the drug UM171 recruit HDAC1/2 complexes through structural mimicry, revealing a common mechanism for their degradation.
10 citations - NeurosciencebioRxivPreprint
Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states
Anna Li, Ashley C. W. Pike, Richard G. Webster…·Yin Yao Dong
The paper presents structures of human adult muscle-type nicotinic receptors in resting and desensitised states and examines the effects of genetic variants on channel function.
DOI 10.1101/2024.12.13.624530 - BiochemistryNature Structural & Molecular BiologyPeer-reviewed
Structural basis of the mechanism and inhibition of a human ceramide synthase
Tomas C. Pascoa, Ashley C. W. Pike, Christofer S. Tautermann…·David Bryant Sauer
This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.
29 citations