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This study identifies an endothelial-specific Ovol1 variant that upregulates Slug and drives pathological angiogenesis in disease models.

This study examines how trait mindfulness affects cortisol changes and mood reactivity after a negative mood induction, finding that mindfulness moderates these relationships.

DEEPNET-LLM predicts unknown metabolite structures from mass spectra by leveraging molecular neighborhoods, achieving high accuracy in de novo structure prediction.

The paper benchmarks AI models for predicting mutational effects and drug-target affinity using deep mutational scanning data, finding that current models fail to capture inhibitor-dependent fitness landscapes.

The study examines life-history trade-offs in Aedes aegypti across developmental stages, finding stage- and sex-specific responses to predation risk.

The paper introduces HiCONA, a Bayesian framework that identifies mitotically preserved chromatin interactions guiding post-mitotic 3D genome reassembly and epigenetic memory.

This paper introduces an automated method using singular value decomposition to analyze NMR fraction libraries for molecular component identification and quantification.

This study uses Aggregate Deep Visual Proteomics to show that α-synuclein inclusions selectively concentrate specific proteins in neurons, revealing their formation mechanisms and potential therapeutic targets.

The paper uses AI to model 109,282 human protein interactions, maps pathogenic variants to these structures, and identifies interface mutations in disease contexts.

This study identifies Blp4 as a Cryptococcus neoformans antigen that elicits B cell-dependent protective immunity in mice and antibody responses in human cryptococcosis survivors.

This study shows that RyR2-mediated Ca2+ leak causes arrhythmias and progressive cardiomyopathy in rabbits, identifying RyR2 as a therapeutic target.

This paper improves variant-effect prediction in sequence-to-function models using synthetic MPRA data generated from distilled model predictions.

The paper introduces a simulator for accurately modeling gene regulatory dynamics across large-scale eukaryotic gene sets using a biophysical chemical master equation.

The paper introduces eQIF, an unsupervised machine-learning method that integrates Enformer predictions to prioritize gene-regulatory variants, showing strong performance in predicting eQTLs and GWAS variants.

This study compares oogenesis in annual and non-annual killifishes, finding conserved developmental stages but divergent zona pellucida features in the annual species.

This study assesses whether hydroquinone induces aneuploidy in hematopoietic stem cells using KaryoTap and FISH, finding no reproducible increase in whole-chromosome aneuploidy.

The paper examines how cortical bursts influence phase synchrony development in preterm infants and links persistent phase-based connectivity to poorer neurocognitive outcomes.

The paper shows that dermal-epidermal junction geometry influences stem cell fate in mouse skin, with concave areas promoting proliferation and convex areas promoting differentiation.

This study reconstitutes OATP1B1 and OATP1B3 in proteoliposomes to show bicarbonate gradients drive substrate uptake, with EGCG enhancing OATP1B3 transport.

This study identifies GNG2 as an inhibitor of the SMP complex by binding MRAS, disrupting its assembly and inhibiting MAPK signaling.