Kaspar P. Locher

This study reconstitutes OATP1B1 and OATP1B3 in proteoliposomes to show bicarbonate gradients drive substrate uptake, with EGCG enhancing OATP1B3 transport.

The paper determines the cryo-EM structure of bulevirtide bound to NTCP, revealing its mechanism of inhibiting HBV/HDV entry and providing insights for drug development.

The paper develops nanobodies targeting the human transcobalamin-mediated vitamin B12 uptake route and shows their potential to inhibit cancer cell growth.

The paper develops a synthetic Fab module (NabFab) that binds nanobodies with high affinity, enabling high-resolution cryo-EM studies of membrane proteins.