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vafSOMA detects cell-layer-fixed somatic mutations in plants using tissue composition, improving mutation detection and rate estimation in bulk sequencing data.

SeCAT is a Nextflow pipeline that harmonizes 16S rRNA metabarcoding datasets by identifying a consensus sequence window and testing its impact on community structure before merging datasets.

SPaRTA enables non-experts to query spatial-omics data via natural language, achieving 63-77% accuracy with fine-tuning on cancer tissue datasets.

The paper investigates how different humanized tau isoforms and mutations affect synaptic connectivity and interact with mitochondrial proteins in cortical neurons.

This study identifies MET signaling as a targetable vulnerability in rhabdoid tumors through integrated single-cell multi-omic and spatial transcriptomics analyses.

This study shows that Fc-FGF21's weight-loss efficacy depends on its circulating half-life, which is influenced by hTfR binding valency and BBB transport.

The paper evaluates an eight-gene module associated with trogocytosis in CRC, finding its correlation with T-cell fraction is typical of random modules, suggesting it reflects cellular composition rather than trogocytosis.

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

This paper introduces LSAT-EN, a transfer learning method that improves survival prediction for younger breast cancer patients using multi-omics data from older patients.

The paper shows that external focus suppresses internal thoughts, creating an amnesic shadow that inhibits both novel and existing memories.

This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.

The paper analyzes fMRI data to show that temporal specificity in recall is preserved despite reorganization of feature representations across the cortex during recall of a narrative episode.

The paper models multispecies transport through gasdermin pores to explain how pore formation leads to cell swelling and osmotic changes.

This study examines mating behavior, mate choice, and reproductive outcomes in Tyrophagus curvipenis, finding that mating frequency affects fecundity but not pre-oviposition period.

The paper identifies native T-DNA transfer systems in rhizobia that deliver cargo genes into legume nodules, showing they share similarities with Agrobacteria-mediated transformation but have distinct regulatory mechanisms.

This study investigates the role of the fruitless P3 transcript in Drosophila development, finding it essential for pupal development and metamorphosis, with distinct effects compared to complete fruitless loss.

The paper assesses chemical pollution and ecotoxicological risks in Caribbean coastal bays and coral reefs using chemical analysis and bioassays, finding that bays act as pollution sources while reefs show mixture toxicity.

The paper investigates how electrostatic interactions control conformational changes and proton translocation in Complex I using a combination of experimental and computational methods.

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

This study investigates how the multiple-demand network maintains working memory during task interruptions, finding that neural representations of category information remain stable despite behavioral costs.