Erik B. Bloss

The paper investigates how different humanized tau isoforms and mutations affect synaptic connectivity and interact with mitochondrial proteins in cortical neurons.

The paper characterizes the AppSAA knock-in mouse model, showing it recapitulates age-dependent Alzheimer's disease phenotypes and provides a tool for preclinical research.

The paper shows that male and female mice use different synaptic plasticity mechanisms for fear extinction, with males showing structural remodeling and GRIN2B dependence, while females do not.

The paper investigates age-related synaptic changes in two mouse strains, finding differential synaptic loss and efficiency in specific circuits, suggesting genetic factors influence cognitive decline resistance.

The paper shows genetic context influences microglia-synaptic interactions in AD mouse models, with differential effects in B6 and PWK strains.

The paper identifies distinct synaptic microcircuits in the mouse frontal cortex, showing hippocampal and thalamic afferents target different inhibitory and excitatory neuron classes.