BioengineeringbioRxiv
Understanding Activity-Stability Tradeoffs in Biocatalysts by Enzyme Proximity Sequencing
R. Vanella, C. Kueng, A. A. Schoepfer…·M. Nash
The paper introduces EP-Seq, a method to simultaneously measure enzyme stability and activity across thousands of mutations, and applies it to D-amino acid oxidase to identify activity-stability tradeoffs.
DOI 10.1038/s41467-024-45630-3