J. Ren

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

The paper shows WTAP undergoes phase transition during IFN-β stimulation to regulate m6A modification of ISG mRNAs and control their expression.

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels

This paper develops a method to create stiffness gradients in alginate hydrogels using stencils, enabling the study of mechanosensitive cell behaviors like cancer cell invasion.

Signal Antagonists Suppress Pseudomonas syringae Pathogenicity

This study designs and synthesizes leudiazen analogs that inhibit Pseudomonas syringae virulence without killing the bacteria, reducing resistance risk.

CAMSAP3 Forms Dimers via its lapha-helix Domain that Directly Stabilize Non-centrosomal Microtubule Minus Ends

This study identifies how CAMSAP3 dimerizes via its C-terminal alpha-helix to stabilize non-centrosomal microtubule minus ends through enhanced CKK domain binding.

Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2

This study identifies DNMT3B as a promoter of colorectal cancer cell proliferation by inhibiting PLCG2 transcription through promoter methylation.

Functional Biosynthetic Stereodivergence in a Gene Cluster via a Dihydrosydnone N-oxide

The paper investigates a gene cluster that produces both enantiomerically pure and racemic metabolites through a stereodivergent pathway involving a dihydrosydnone N-oxide intermediate.

Matrix Vesicles from Osteoblasts Promote Atherosclerotic Calcification

This study shows osteoblast-derived matrix vesicles (Ost-MVs) contribute to atherosclerotic calcification by being released into circulation and transported to plaques, where they exacerbate calcification through the Ras-Raf-ERK pathway.

Structural plasticity of 2A proteins in the Parechovirus family

The paper investigates structural plasticity in Parechovirus 2A proteins, revealing structural rearrangements that affect their oligomeric state and potential function in viral RNA replication.

Comparison of chronic aerosol inhalation with combustible cigarette and e-cigarette on the psychiatric behaviors and neuroimmune profile in mice

This study compares the effects of combustible cigarette and e-cigarette aerosol inhalation on psychiatric behaviors and neuroimmune profiles in mice, finding greater anxiety in combustible cigarette exposure.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

This paper identifies Acb2 as a phage-encoded protein that sequesters multiple cyclic dinucleotides and trinucleotides, inhibiting CBASS immunity.

Understanding Activity-Stability Tradeoffs in Biocatalysts by Enzyme Proximity Sequencing

The paper introduces EP-Seq, a method to simultaneously measure enzyme stability and activity across thousands of mutations, and applies it to D-amino acid oxidase to identify activity-stability tradeoffs.

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

The deacetylase dependent and independent role of HDAC3 in cardiomyopathy

This study investigates the deacetylase-dependent and independent roles of HDAC3 in cardiomyopathy using Drosophila, finding it maintains cardiac contractility and prevents Pericardin deposition independently of its deacetylase activity, but regulates triglyceride homeostasis through this activity.

The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells

This study identifies Cul5 as a negative feedback regulator of CD8+ T cell signaling and anti-tumor activity, showing its knockout enhances tumor control through proteomic and signaling changes.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.

Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism

This study shows that CD45-linked NKR antagonists enhance NK and T cell activity more than traditional antibodies, revealing potential for improved cancer immunotherapies.

Biosynthetic diversification of peptaibol mediates fungus-mycohost interactions

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

Selection and validation of reference genes for quantitative real-time polymerase chain reaction in Serratia ureilytica DW2

This study identifies and validates stable reference genes for RT-qPCR in Serratia ureilytica DW2 under various conditions.

Dynamic changes of gut microbiota associated with blood glucose levels in sows from pregnancy through lactation

This study examines how restricted feeding during gestation affects blood glucose levels and gut microbiota in sows across pregnancy and lactation stages.

Effects of immunomodulatory peptides derived from a soil bacterium on cecal microbiota of broilers challenged with Clostridium perfringens

This study compares the effects of immunomodulatory BT peptide and antibiotics on cecal microbiota in broilers challenged with Clostridium perfringens, finding differences in microbial composition and function.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection

This study investigates MCT deficiency in Syrian hamsters infected with SARS-CoV-2, finding a 67% reduction in MCT rate by 2 dpi due to decreased motile ciliation.

HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancer

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

The PD-L1 and TLR7 dual-targeting nanobody-drug conjugate exerts potent antitumor efficacy by orchestrating innate and adaptive immune responses

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.