Author

R. Vanella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Kueng· 2 shared M. Nash· 2 shared A. A. Schoepfer· 1 shared B. Yang· 1 shared D. E. B. Gomes· 1 shared J. Ren· 1 shared M. A. Nash· 1 shared O. Protsenko· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBioengineering

C. Kueng

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Author profile →

3 papers

Recent·Most cited

Deep Mutational Scanning Reveals a De Novo Disulfide Bond and Combinatorial Mutations for Engineering Thermostable Myoglobin

C. Kueng, O. Protsenko, R. Vanella, M. Nash

This study uses deep mutational scanning to identify mutations that enhance thermostability in human myoglobin, discovering a de novo disulfide bond and combinatorial mutations that significantly increase stability.

bioRxiv · Feb 24, 2024Bioengineering

Integrating Dynamic Network Analysis with AI for Enhanced Epitope Prediction in PD-L1:Affibody Interactions

D. E. B. Gomes, B. Yang, R. Vanella, M. A. Nash, R. C. Bernardi

The paper develops an integrated method combining dynamic network analysis with AI to predict epitopes in PD-L1:Affibody interactions, showing the perpendicular binding mode is more stable.

bioRxiv · Feb 8, 2024Biophysics

Understanding Activity-Stability Tradeoffs in Biocatalysts by Enzyme Proximity Sequencing

R. Vanella, C. Kueng, A. A. Schoepfer, V. Doffini, J. Ren, M. Nash

The paper introduces EP-Seq, a method to simultaneously measure enzyme stability and activity across thousands of mutations, and applies it to D-amino acid oxidase to identify activity-stability tradeoffs.

bioRxiv · Feb 24, 2023Bioengineering