A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells
M. Wang, A. Graner, B. Knowles, C. McRae, A. Fringuello, P. Paucek, M. Gavrilovic, M. Redwine, C. Coughlan, C. Hanson, B. Metzger, V. Bolus, T. Kopper, M. Smith, W. Zhou, , M. W. Graner
This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.
bioRxiv · Apr 8, 2024 · PreprintCancer Biology