W. Zhou

Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice

This study shows that hypercholesterolemia causes coronary microvascular dysfunction in mice through enhanced lysosomal signaling in endothelial cells, which can be mitigated by ezetimibe.

Additive and partially dominant effects from genomic variation contribute to rice heterosis

This study identifies heterosis-associated genes and metabolites in rice, showing additive and partially dominant genetic effects contribute to 17 agronomic traits and yield heterosis across species.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Dynamic Localization of Leukemia Stem Cells via CXCL12 Regulates Leukemia Progression

This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.

CREEPING STEM1 Regulates Directional Auxin Transport for Lodging Resistance in Soybean

This study identifies the CS1 gene in soybean, which regulates directional auxin transport and enhances lodging resistance, improving yield under high planting density.

Genotype-environment-driven dysbiosis in the skin microbiome of ichthyosis

This study shows that ichthyosis genotype, phenotype, and host factors influence the skin microbiome's species, strain, and metabolic pathway composition.

Transformer-based modeling of Clonal Selection and Expression Dynamics (TraCSED) reveals resistance signatures in breast cancer

TraCSED identifies resistance pathways in breast cancer by analyzing scRNA-seq data and clonal selection dynamics over time.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish

The study shows that the intestinal microbiome, specifically Cetobacterium somerae, inhibits viral infection in zebrafish via a TLR2-type I IFN signaling pathway.

LncCE: Landscape of Cellular-Elevated LncRNAs in Single Cells Across Normal and Cancer Tissues

LncCE identifies and characterizes cellular-elevated lncRNAs across normal and cancer tissues using single-cell RNA sequencing data, providing expression patterns and clinical associations.

Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases

The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS

The paper shows that HIV-1 capsids protect reverse-transcribed DNA from cGAS detection, and that disrupting the capsid enhances cGAS activity.

Microbial Analysis and Sanitization of Hydroponic Farming Facilities in Singapore

This study identifies biofilm-forming bacteria in hydroponic systems and evaluates sanitization solutions, finding sodium hypochlorite most effective for biofilm removal.

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells

This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.

Large-scale statistical mapping of T-cell receptor β sequences to Human Leukocyte Antigens

The paper maps T-cell receptor β sequences to specific HLA allotypes using population-level TCR repertoire data, enabling accurate HLA imputation and revealing insights into TCR-HLA interactions.

Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay

This study uses SMOLM to analyze A{beta}42 fibril architecture and dynamics, finding that order and heterogeneity correlate with growth and decay.

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

Construction and application of a technical platform for determining cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles

This study constructs a technical platform to investigate cell cycle- and autophagy-related nanoparticle accumulation, revealing distinct accumulation patterns in specific cell cycle phases.

Regulatory divergences in dosage compensation cause hybrid male inviability in Caenorhabditis

Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

Deciphering the gut microbiome of grass carp through multi-omics approach

The paper uses a multi-omics approach to analyze the gut microbiome of grass carp, identifying two functional groups and proposing a biomarker for microbiota structure and function.

Pharmacologically inducing regenerative cardiac cells by small molecule drugs

This study shows that a two-drug combination induces regenerative cardiac cells from cardiomyocytes in vitro and in vivo, improving heart function after injury.

Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and their Zebrafish Homologs at the Blood-Brain Barrier

The paper identifies NanoLuciferase substrates transported by human and zebrafish ABC transporters at the BBB, aiding in the development of a transgenic zebrafish model to detect BBB disruptors.

RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia

This study shows that non-core RAG regions reduce off-target V(D)J recombination and maintain genomic stability in BCR-ABL1+ B-ALL by improving RAG cleavage accuracy.

Resolving the nanoscale structure of β-sheet assemblies using single-molecule orientation-localization microscopy

This study uses single-molecule orientation-localization microscopy to analyze the structure and polymorphism of engineered and pathological cross-beta fibrils.

O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma

This study identifies O-GlcNAcylation of YTHDF2 at Thr-49 as a regulator of ERK-dependent phosphorylation and tumor growth in lung carcinoma.

Rof is a key regulator of Rho and transcription termination in bacteria

This study reports the cryo-EM structure of the Rho-Rof antitermination complex and shows Rof inhibits Rho-dependent termination, essential for bacterial virulence.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Positive selection and relaxed purifying selection contribute to rapid evolution of male-biased genes in a dioecious flowering plant

This study identifies rapid evolution in male-biased genes of dioecious Trichosanthes pilosa, driven by positive selection and relaxed purifying selection, with functions related to stress and immunity.