M. Smith

An epigenetically distinct HSC subset supports thymic reconstitution

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

High variability of migration strategies in a re-established Trumpeter Swan population

The paper tracks migration strategies in re-established trumpeter swans, finding 59% engage in long-distance migration, with movement patterns linked to breeding status and latitude.

The sensory shark: high-quality morphological, genomic and transcriptomic data for the small spotted catshark Scyliorhinus canicula reveal the molecular bases of sensory organ evolution in jawed vertebrates

This study integrates genomic, transcriptomic, and morphological data from the small-spotted catshark to uncover molecular mechanisms underlying sensory organ evolution in jawed vertebrates.

Duration of Morning Hyperinsulinemia Determines Hepatic Glucose Uptake and Glycogen Storage Later in the Day

The study shows that prolonged morning hyperinsulinemia improves hepatic glucose uptake and glycogen storage during an afternoon clamp compared to shorter, higher-rate insulin delivery.

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells

This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.

Characterization of Arabidopsis aldolases AtFBA4 and AtFBA5; inhibition by morin and interaction with calmodulin

This study characterizes Arabidopsis aldolases AtFBA4 and AtFBA5, showing CaM binding to AtFBA5 and inhibition by morin.

Resistify - A rapid and accurate annotation tool to identify NLRs and study their genomic organisation

Resistify identifies and classifies NLRs in plant genomes with high accuracy and speed, revealing a new association between NLRs and Helitron transposable elements.

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

Multifunction Fluorescence Open-Source In Vivo/In Vitro Imaging System (openIVIS)

The paper describes an open-source fluorescent imaging system (openIVIS) that can be used for in vivo and in vitro applications, demonstrating its versatility and low cost.

Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog

This study examines how glucagon affects hepatic glucose production and gene expression in conscious dogs over time, revealing transient metabolic flux changes and gene regulation patterns.

"Tranq-Dope" Overdose and Mortality: Lethality Induced by Fentanyl and Xylazine

This study quantifies the lethal effects of fentanyl-xylazine combinations in mice and shows naloxone can reduce lethality.

The beta 6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

The influence of carbon dioxide on cerebral metabolism and oxygen consumption: combining multimodal monitoring with dynamic systems modelling

This study combines multimodal monitoring with dynamic systems modeling to investigate how hypercapnia affects cerebral metabolism and oxygen consumption in humans.

Machine Learning to Predict Continuous Protein Properties from Simple Binary Sorting and Deep Sequencing Data

This paper develops a machine learning framework to predict continuous protein properties from deep sequencing data in directed evolution experiments, demonstrating its effectiveness across multiple protein engineering tasks.

Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.

Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age

The paper reanalyzes naked mole-rat mortality data, confirms previous findings that mortality rates do not increase with age, and compares them to related mole-rat species.

Development of Fully Human, Bispecific Antibodies that Effectively Block Omicron Variant Pseudovirus Infections

This study develops fully human bispecific antibodies that effectively block Omicron variant pseudovirus infections, showing improved neutralization compared to monoclonal antibodies.

Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas

This paper develops a finite element model of the chinchilla inner ear to study how CI electrode insertion angle affects residual hearing, finding minimal hearing loss with optimal angles.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Redox-active molecules in bacterial cultivation media produce photocurrent.

The paper shows that redox-active molecules in bacterial cultivation media can generate photocurrent in a bio-electrochemical cell.

Intracellular calcium elevations drive the nucleation of FIP200- and ATG13-containing pre-autophagosomal structures that become omegasomes

This study shows that sustained intracellular calcium elevations drive the formation of FIP200- and ATG13-containing pre-autophagosomal structures called omegasomes, but not full autophagosomes.

Non-catastrophic collapse of VEEV by lethal mutagenesis

This study investigates how Venezuelan Equine Encephalitis Virus (VEEV) responds to RNA mutagen treatment, finding that replication-competent subpopulations persist with lower mutation frequency and increased adaptability.

Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations

This study identifies a longer, oncogenic IRAK4 isoform caused by SF3B1 mutations in MDS/AML, which is targetable by IRAK4 inhibition.

Caecilian genomes reveal molecular basis of adaptation and convergent evolution of limblessness in snakes and caecilians.

The paper analyzes caecilian genomes to identify molecular mechanisms underlying limblessness and convergent evolution with snakes, finding shared genetic targets involved in limb development.

Genetic load in incomplete lupus erythematosus

This study compares the genetic load of SLE risk alleles in ILE and SLE patients, finding comparable genetic predisposition despite phenotypic differences.

Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms

The paper investigates how mitotic spindles reorient in response to mechanical stress and finds that spindle rotation emerges from interactions between positioning machinery and cortical tension.

Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

This study compares high-volume and high-load resistance training on muscle growth and molecular markers, finding similar hypertrophic and strength adaptations despite differences in protein synthesis rates.

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner

This study analyzes SARS-CoV-2 mutations to show how they diversify T cell targets in an HLA supertype-dependent manner, leading to epitope loss in B7 supertype carriers.

Species Tree Inference on Data with Paralogs is Accurate Using Methods Intended to Deal with Incomplete Lineage Sorting

This study shows that species tree inference methods can accurately handle data with paralogs, even when incomplete lineage sorting is present.

Structure-aided development of small molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP

This study develops small molecule ENPP1 inhibitors with sub-nanomolar potency and demonstrates their efficacy in delaying tumor growth in a breast cancer model.