Author

B. Knowles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Abosch· 1 shared A. Fringuello· 1 shared A. G. Heriot· 1 shared A. Graner· 1 shared A. K. Elefanty· 1 shared A. Kong· 1 shared A. M. Fox· 1 shared A. Puisieux· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Abosch

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells

M. Wang, A. Graner, B. Knowles, C. McRae, A. Fringuello, P. Paucek, M. Gavrilovic, M. Redwine, C. Coughlan, C. Hanson, B. Metzger, V. Bolus, T. Kopper, M. Smith, W. Zhou, , M. W. Graner

This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Liver-specification of human iPSC-derived endothelial cells transplanted into mouse liver

K. K. Yap, J. Schroeder, Y.-W. Gerrand, A. Kong, A. M. Fox, B. Knowles, S. W. Banting, A. K. Elefanty, E. G. Stanley, G. C. Yeoh, G. P. Lockwood, V. C. Cogger, W. A. Morrison, J. M. Polo, G. M. Mitchell

This study transplants human iPSC-derived endothelial cells into mice to generate LSEC-like cells, identifies key transcription factors and markers for LSEC specification, and provides a model for studying liver endothelial development.

bioRxiv · Jun 28, 2023Cell Biology

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

C. Behrenbruch, M. Foroutan, P. Lind, J. Smith, M. Grandin, B. Cooper, C. Shembrey, S. Ramm, K. Cowley, I. Nikolic, J. Liuu, J. Cursons, R. Millen, A.-M. Patch, N. D. Huntington, , F. Hollande

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

bioRxiv · Feb 4, 2021 · PreprintCancer Biology