Author

A. Aguzzi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 5 Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

A. Ilsley· 3 shared A. S. Morgunov· 3 shared A. Y. Malik· 3 shared G. Meisl· 3 shared H. Fiegler· 3 shared M. A. Piziorska· 3 shared M. Emmenegger· 3 shared M. M. Schneider· 3 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

A. Ilsley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2

V. Denninger, C. K. Xu, G. Meisl, A. S. Morgunov, S. Fiedler, A. Ilsley, M. Emmenegger, A. Y. Malik, M. A. Piziorska, M. M. Schneider, S. R. A. Devenish, V. Kosmoliaptsis, A. Aguzzi, H. Fiegler, T. P. J. Knowles

This study uses microfluidic antibody-affinity profiling to assess cross-reactive antibodies against SARS-CoV-2 in convalescent patients and pre-pandemic sera, finding low affinity and concentration against SARS-CoV-2 spike protein.

bioRxiv · Jul 23, 2021 · PreprintBiophysics

Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape

S. Fiedler, V. Denninger, A. S. Morgunov, A. Ilsley, R. Worth, G. Meisl, C. K. Xu, M. A. Piziorska, F. Ricci, A. Y. Malik, S. R. A. Devenish, M. M. Schneider, V. Kosmoliaptsis, A. Aguzzi, A. Iwasaki, , T. P. J. Knowles

This study compares antibody escape mechanisms in SARS-CoV-2 alpha and beta variants, finding they use distinct strategies: alpha increases ACE2 binding affinity, while beta alters epitopes to reduce antibody access.

bioRxiv · Jul 23, 2021 · PreprintBiochemistry

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

M. Emmenegger, S. S. Kumar, V. Emmenegger, T. Malinauskas, T. Buettner, L. Rose, P. Schierack, M. F. Sprinzl, C. J. Sommer, K. J. Lackner, A. Aguzzi, D. Roggenbuck, K. B. M. Frauenknecht

This study finds that anti-prothrombin autoantibodies are enriched after SARS-CoV-2 infection and linked to antibody response strength and disease severity.

bioRxiv · Jun 21, 2021Immunology

In vitro measurements of protein-protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

S. Fiedler, M. A. Piziorska, V. Denninger, A. S. Morgunov, A. Ilsley, A. Y. Malik, M. M. Schneider, S. R. A. Devenish, G. Meisl, A. Aguzzi, H. Fiegler, T. P. J. Knowles

The paper measures how antibody affinity affects the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum using in vitro assays.

bioRxiv · Dec 20, 2020 · PreprintBiochemistry

Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19

C. Cervia, J. Nilsson, Y. Zurbuchen, A. Valaperti, J. Schreiner, A. Wolfensberger, M. E. Raeber, S. Adamo, M. Emmenegger, S. Hasler, P. P. Bosshard, E. De Cecco, E. Baechli, A. Rudiger, M. Stuessi-Helbling, , O. Boyman

This study compares SARS-CoV-2-specific antibody responses in mild and severe COVID-19 patients and healthcare workers, finding higher systemic IgA and IgG in severe cases and mucosal IgA in asymptomatic exposed individuals.

bioRxiv · May 21, 2020Immunology