Author

H. Fiegler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Organism:human· 2 Organism:virus· 1

Frequent Co-Authors

S. Fiedler· 4 shared S. R. A. Devenish· 4 shared A. Aguzzi· 3 shared A. Ilsley· 3 shared A. S. Morgunov· 3 shared A. Y. Malik· 3 shared C. K. Xu· 3 shared G. Meisl· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

S. Fiedler

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Alpha-synuclein oligomers displace monomeric alpha-synuclein from lipid membranes

G. Sneideriene, M. A. Czekalska, C. K. Xu, A. Jayaram, G. Krainer, W. E. Arter, Q. Peter, M. Castellana-Cruz, K. L. Saar, A. Levin, T. Mueller, S. Fiedler, S. R. A. Devenish, H. Fiegler, J. R. Kumita, T. Knowles

This study shows that alpha-synuclein oligomers bind more strongly to curved lipid membranes and displace monomeric alpha-synuclein, suggesting a new mechanism for Parkinson's disease toxicity.

bioRxiv · Mar 21, 2023Biophysics

Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2

V. Denninger, C. K. Xu, G. Meisl, A. S. Morgunov, S. Fiedler, A. Ilsley, M. Emmenegger, A. Y. Malik, M. A. Piziorska, M. M. Schneider, S. R. A. Devenish, V. Kosmoliaptsis, A. Aguzzi, H. Fiegler, T. P. J. Knowles

This study uses microfluidic antibody-affinity profiling to assess cross-reactive antibodies against SARS-CoV-2 in convalescent patients and pre-pandemic sera, finding low affinity and concentration against SARS-CoV-2 spike protein.

bioRxiv · Jul 23, 2021 · PreprintBiophysics

Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape

S. Fiedler, V. Denninger, A. S. Morgunov, A. Ilsley, R. Worth, G. Meisl, C. K. Xu, M. A. Piziorska, F. Ricci, A. Y. Malik, S. R. A. Devenish, M. M. Schneider, V. Kosmoliaptsis, A. Aguzzi, A. Iwasaki, , T. P. J. Knowles

This study compares antibody escape mechanisms in SARS-CoV-2 alpha and beta variants, finding they use distinct strategies: alpha increases ACE2 binding affinity, while beta alters epitopes to reduce antibody access.

bioRxiv · Jul 23, 2021 · PreprintBiochemistry

In vitro measurements of protein-protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

S. Fiedler, M. A. Piziorska, V. Denninger, A. S. Morgunov, A. Ilsley, A. Y. Malik, M. M. Schneider, S. R. A. Devenish, G. Meisl, A. Aguzzi, H. Fiegler, T. P. J. Knowles

The paper measures how antibody affinity affects the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum using in vitro assays.

bioRxiv · Dec 20, 2020 · PreprintBiochemistry