J. Nilsson

Data of the Insect Biome Atlas: a metabarcoding survey of the terrestrial arthropods of Sweden and Madagascar

The paper presents comprehensive DNA metabarcoding data from Sweden and Madagascar, characterizing terrestrial arthropod faunas and providing insights into community composition and dynamics.

CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma

This study identifies four subgroups of osteosarcomas based on genomic and transcriptomic analysis, revealing distinct mechanisms of CDK4 amplification in relation to MDM2 or TP53 alterations.

Substrate recognition principles for the PP2A-B55 protein phosphatase

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

The paper characterizes how disease mutations in intrinsically disordered regions modulate protein interactions mediated by short linear motifs, identifying both loss and gain of interactions.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

This study identifies a novel interaction between SARS-CoV-2 NSP3 and FMRPs, showing that this interaction is critical for viral replication and disease progression.

Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19

The paper reports cryo-EM structures of PP2A:B55 bound to phosphorylated ARPP19 and FAM122A, revealing distinct binding mechanisms and providing insights for therapeutic development.

Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling

This study functionally analyzes Cdc20's role in mitotic checkpoint signaling by identifying the CRY box's critical role in SAC through MCC formation and APC/C interaction.

Global substrate identification and high throughput in vitro dephosphorylation reactions uncover PP1 and PP2A-B55 specificity principles

The paper develops an in vitro assay to determine phosphatase specificity and applies it to study mitotic exit, revealing substrate preferences and biological relevance.

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

The paper investigates the role of IL-5+ lymphocytes and type 3/17 lymphocytes in liver fibrosis, showing their spatial relationship and cross-regulation in fibroblast niches.

Fate and plasticity of SARS-CoV-2-specific B cells during memory and recall response in humans

The paper tracks SARS-CoV-2-specific memory B cell fate transitions in humans, showing single clones can adopt distinct functional trajectories during memory and recall responses.

Large-scale identification of phospho-modulated motif-based protein-protein interactions

The paper identifies 252 phospho-modulated short linear motif-based protein-protein interactions using a proteomic peptide-phage display library and validates several through affinity measurements and structural analysis.

Separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis

This study shows that separating kinase and phosphatase activities in the Bub complex is essential for proper mitosis, as merging these functions leads to mitotic defects.

A conserved PLK1 docking site in TopBP1 maintains genome integrity during mitosis

This study identifies a conserved PLK1 docking site in TopBP1 that is essential for maintaining genome integrity during mitosis, as its deletion increases DNA damage and mitotic errors.

Generation and diversification of recombinant monoclonal antibodies for studying mitosis

This study develops methods to generate low-cost, high-yield recombinant monoclonal antibodies and antibody fragments for studying mitosis and other applications.

CD8+ T cell signature in acute SARS-CoV-2 infection identifies memory precursors

The paper identifies a transcriptional signature in SARS-CoV-2-specific CD8+ T cells that distinguishes short-lived from long-lived memory cells one year post-infection.

Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting

This study challenges previous claims that iHAP1 and DT-061 target PP2A-B56 complexes, showing instead that they exert toxicity through microtubule disruption and ER/Golgi disruption, respectively.

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

The paper identifies coronavirus-host protein interaction motifs, revealing SARS-CoV-2 specific mechanisms and a peptide-based inhibitor that blocks infection.

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

This study identifies the BRCA2-PP2A-B56 complex as essential for efficient DNA repair by homologous recombination and shows that cancer mutations disrupt this interaction, increasing sensitivity to PARP inhibition.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection

This study identifies a conserved binding pocket on PP2A-B56 essential for Sgo1 interaction and cohesion protection, showing that complex formation is not strictly required for cohesion protection.

Coupling of Cdc20 inhibition and activation by BubR1

This study shows BubR1 has both inhibitory and activating roles in Cdc20, enabling dephosphorylation by PP2A-B56 in the MCC while preventing premature anaphase.

Revealing interspecies transmission barriers of avian influenza A viruses

This study investigates interspecies transmission barriers of avian influenza A viruses by analyzing infection dynamics, receptor expression, and host responses in different avian hosts.

A distinct innate immune signature marks progression from mild to severe COVID-19

The paper identifies an innate immune signature associated with progression from mild to severe COVID-19 using mass cytometry and proteomics.

Lymphopenia-induced T cell proliferation is a hallmark of severe COVID-19

This study identifies T cell apoptosis and migration as mechanisms of peripheral T cell lymphopenia in severe COVID-19 and links lymphopenia to subsequent T cell proliferation.

Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19

This study compares SARS-CoV-2-specific antibody responses in mild and severe COVID-19 patients and healthcare workers, finding higher systemic IgA and IgG in severe cases and mucosal IgA in asymptomatic exposed individuals.

Dysregulated gene expression through TP53 promoter swapping in osteosarcoma

This study investigates how TP53 promoter swapping in osteosarcoma leads to dysregulated gene expression and oncogenic activation.

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

This study shows that GLP-1R is downregulated in beta cells of NOD mice and T1D patients, likely due to accelerated degradation, and suggests a role in autoimmune inflammation.

Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila

This study identifies Windpipe as a chondroitin sulfate proteoglycan that modulates Hedgehog signaling in Drosophila by regulating Smoothened stability.

The closed form of Mad2 is bound to Mad1 and Cdc20 at unattached kinetochores

This study shows Cdc20 and C-Mad2 levels correlate at kinetochores and that Cdc20 depletion reduces Mad2 levels, suggesting Mad2-Cdc20 complexes exist at kinetochores.