Author

A. Aina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:deep learning· 3 Research Focus:benchmarking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:proteomics· 2

Frequent Co-Authors

S. C. C. Hsueh· 4 shared S. S. Plotkin· 4 shared N. R. Cashman· 2 shared X. Peng· 2 shared A. Y. Roman· 1 shared E. Gibbs· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 14 mutual co-author links

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4 shared papersBiophysics

S. C. C. Hsueh

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Author profile →

4 papers

Recent·Most cited

De novo design of a β-helix tau protein scaffold: An oligomer-selective vaccine immunogen candidate for Alzheimer's disease

A. Aina, S. C. C. Hsueh, E. Gibbs, X. Peng, N. R. Cashman, S. S. Plotkin

This paper designs a β-helix tau protein scaffold that mimics toxic tau oligomers and shows selective binding to antibodies, suggesting it could be an effective vaccine immunogen for Alzheimer's disease.

bioRxiv · Jun 8, 2023Bioengineering

PROTHON: A Local Order Parameter-Based Method for Efficient Comparison of Protein Ensembles

A. Aina, S. C. C. Hsueh, S. S. Plotkin

PROTHON efficiently compares protein conformational ensembles using local order parameters, outperforming ENCORE in speed and resource usage.

Journal of Chemical Information and Modeling · May 13, 2023Peer-reviewedBiophysics

Accelerated ensemble generation for cyclic peptides using a Reservoir-REMD implementation in GROMACS

S. C. C. Hsueh, A. Aina, S. S. Plotkin

This paper implements and benchmarks Res-REMD in GROMACS for cyclic peptide ensemble generation, showing it accelerates sampling for some systems but not others.

bioRxiv · Sep 7, 2022 · PreprintBiophysics

Optimizing epitope conformational ensembles using α-synuclein cyclic peptide "glycindel" scaffolds: A customized immunogen method for generating oligomer-selective antibodies for Parkinson's disease

S. C. C. Hsueh, A. Aina, A. Y. Roman, N. R. Cashman, X. Peng, S. S. Plotkin

bioRxiv · Sep 13, 2021Biophysics