X. Peng

YAP/TAZ enhance P-body formation to promote tumorigenesis

This study shows YAP/TAZ promote P-body formation in cancer cells, enhancing tumorigenesis, and suggests targeting P-bodies or PNRC1 could be therapeutic.

Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

This study shows that Lacticaseibacillus rhamnosus P118 enhances host resistance to Salmonella by promoting indole metabolites from gut microbes.

Perirhinal and postrhinal cortices are necessary for retrieving latently-acquired stimulus associations

This study shows that perirhinal and postrhinal cortices are necessary for retrieving latently-acquired stimulus associations in rats using a chemogenetic suppression approach.

Temperature-Dependent Fold-Switching Mechanism of the Circadian Clock Protein KaiB

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

Influences of single mutation and retinal binding on the THz absorption spectra of CRABP-II based rhodopsin mimics

This study uses THz-TDS to analyze how retinal binding and single mutations affect the low-frequency absorption spectra of rhodopsin mimics.

A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

Multilayered interaction between CRISPR-Cas subtype I-A and adjacently encoded Acrs of virus SIRV2

The paper investigates the interaction between CRISPR-Cas subtype I-A and two adjacent Acrs in SIRV2, showing how they modulate viral infectivity and host immunity.

Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response

This study identifies VILMIR, a novel lncRNA upregulated by respiratory viral infections and IFN-β, which modulates the host interferon response.

Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

The paper identifies a gut microbial signature predictive of RhCMV/SIV vaccine efficacy in rhesus macaques using 16S rRNA analysis and compositional data techniques.

OsUVR8b, rather than OsUVR8a, plays a predominant role in rice UVR8-mediated UV-B response.

This study identifies OsUVR8b as the primary mediator of UV-B response in rice, showing it has a stronger role than OsUVR8a in growth inhibition and gene regulation under UV-B exposure.

Perception of Motion Salience Shapes the Emergence of Collective Motions

The paper investigates collective motion patterns in bird flocks and develops a model based on motion salience to explain hierarchy formation and swarm behavior.

Is M1-L121E a good mimic on microbial rhodopsin? A viewpoint from excited-state dynamics

This paper investigates the excited-state dynamics of a microbial rhodopsin mimic, M1-L121E, and finds it captures key features but shows distinct differences in photoreaction dynamics compared to natural rhodopsin.

Identification of potential distribution area for the sweet cherry (Prunus avium) by the MaxEnt model

The paper models the potential distribution of sweet cherry trees in China using the MaxEnt model, identifying key climate factors and suitable regions for cultivation.

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

The paper identifies a peptide that enhances mRNA lipid nanoparticle delivery to CF lung epithelial cells, showing improved mRNA expression in vitro and in vivo.

Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity

This study investigates Uloboridae spiders' venom loss and toxicity, finding they lack venom glands but retain toxin-like genes in digestive fluids with different toxic mechanisms.

Effect of Acute Stress on Working Memory in Pilots: Investigating the Modulatory Role of Memory Load

This study examines how acute stress affects working memory in pilots under varying memory loads, finding an interaction where stress may improve accuracy in moderate loads.

Pontiella agarivorans sp. nov., a novel marine anaerobic bacterium capable of degrading macroalgal polysaccharides and fixing nitrogen

De novo design of a β-helix tau protein scaffold: An oligomer-selective vaccine immunogen candidate for Alzheimer's disease

This paper designs a β-helix tau protein scaffold that mimics toxic tau oligomers and shows selective binding to antibodies, suggesting it could be an effective vaccine immunogen for Alzheimer's disease.

The central nervous system is a potential reservoir and possible origin of drug resistance in HBV

This study finds HBV can persist in cerebrospinal fluid, showing distinct mutations and resistance patterns compared to serum, and HIV co-infection increases resistance mutations in both compartments.

ARPC5 deficiency leads to severe early onset systemic inflammation and early mortality

This study identifies ARPC5 deficiency as a cause of severe early-onset systemic inflammation and early mortality in humans and mice.

To be or not to be an anti-CRISPR: AcrIII-1 and the importance of working with native biological systems

This study shows that SIRV2 gp37 lacks anti-CRISPR activity in native infections but provides a replicative advantage through host protein interaction.

Excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Characterization of Three Variants of SARS-CoV-2 in vivo Shows Host-Dependent Pathogenicity in Hamsters

This study compares the pathogenicity of three SARS-CoV-2 variants in different animal models, showing host-dependent outcomes and the importance of model selection.

Matrix Softening Controls Stretch-Induced Cellular Memory and Fibroblast Activation

This study shows that matrix softening influences stretch-induced cellular memory and fibroblast activation, with a model predicting activation levels based on ECM properties.

Intrinsically disordered proteins SAID1/2 condensate on SERRATE/ARS2 for dual inhibition of miRNA biogenesis in Arabidopsis

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.

Linking mesozooplankton and SAR11 bacteria in Oxygen Deficient Zones and the open ocean

The paper links mesozooplankton and SAR11 bacteria in oxygen-deficient zones by showing strong correlations between zooplankton eDNA and SAR11 abundance, suggesting a potential ecological relationship.

A clade of RHH proteins ubiquitous in Sulfolobales and their viruses regulates cell cycle progression

This study identifies aCcr1, an RHH protein in Sulfolobales and their viruses, which regulates cell cycle progression by modulating gene expression related to division and replication.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Suppression of tumor/host intrinsic CMTM6 drives anti-tumor cytotoxicity in a PD-L1 independent manner

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.