De novo design of a β-helix tau protein scaffold: An oligomer-selective vaccine immunogen candidate for Alzheimer's disease
A. Aina, S. C. C. Hsueh, E. Gibbs, X. Peng, N. R. Cashman, S. S. Plotkin
This paper designs a β-helix tau protein scaffold that mimics toxic tau oligomers and shows selective binding to antibodies, suggesting it could be an effective vaccine immunogen for Alzheimer's disease.
bioRxiv · Jun 8, 2023Bioengineering