Phosphatase-independent activity of smooth-muscle calcineurin orchestrates a gene expression program leading to hypertension
P. S. Yunes-Leites, Y. Sun, S. Martinez-Martinez, A. Alfayate, M. Toral, A. Colmenar, A. I. Torralbo, D. Lopez-Maderuelo, S. Mateos-Garcia, D. N. Cornfield, J. Vazquez, J. M. Redondo, M. R. Campanero
This study shows that smooth-muscle calcineurin, independent of its phosphatase activity, drives a gene expression program that causes hypertension.
bioRxiv · Nov 26, 2023Pathology