Microglia protect fungi against copper starvation and promote brain infection
S. H. Mohamed, M. S. Fu, S. Hain, A. Alselami, E. Vanhoffelen, Y. Li, E. Bojang, R. Lukande, E. R. Ballou, R. C. May, C. Ding, G. Vande Velde, R. A. Drummond
This study shows microglia support cryptococcal brain infections by hosting fungal growth and facilitating copper acquisition, and demonstrates that IFNγ can block this process.
bioRxiv · Sep 7, 2022 · PreprintImmunology