C. Ding

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Polarized localization of kinesin-1 and RIC-7 drives axonal mitochondria anterograde transport

The paper identifies kinesin-1 and RIC-7 as polarized transport complexes at the leading end of mitochondria driving anterograde axonal transport in C. elegans.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

Reactive myelopoiesis and FX-expressing monocyte-derived macrophages triggered by chemotherapy promote cancer lung metastasis

This study shows chemotherapy-induced reactive myelopoiesis and FX-expressing macrophages promote cancer lung metastasis through CCL2/CCR2 axis and coagulation-inflammation interplay.

Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes

The paper develops a proteomics-based classifier to predict lymph node metastasis in T1 colorectal cancer using protein expression patterns and machine learning.

Microglia protect fungi against copper starvation and promote brain infection

This study shows microglia support cryptococcal brain infections by hosting fungal growth and facilitating copper acquisition, and demonstrates that IFNγ can block this process.

Recently evolved combination of unique sulfatase and amidase genes enables bacterial degradation of the wastewater micropollutant acesulfame worldwide

The paper identifies two bacterial genes enabling acesulfame degradation, showing their recent evolution and global spread through plasmid transposition.

Intermittent fasting mitigates cognitive deficits in Alzheimer's disease via the gut-brain axis

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

Comparative miRNA Transcriptomics of Mouse and Macaque Reveals MYOC is An Inhibitor for C. neoformans Invasion into Brain

Bile Acid Restrained T Cell Activation Explains Cholestasis Aggravated Hepatitis B Virus Infection

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

Isolation and characterization of a Cyprinid herpesvirus strain YZ01 from apparently healthy goldfish after rising water temperature

The paper isolates and characterizes a Cyprinid herpesvirus strain YZ01 from goldfish exposed to elevated water temperatures, showing high genomic similarity to other C genotype strains.

Cytokinin oxidase/dehydrogenase family genes exhibit functional divergence and overlap in rice growth and development, especially in control of tillering

This study investigates the functional roles of OsCKX genes in rice by generating mutants, revealing functional overlap and subfunctionalization, and identifying gene expression changes related to auxin and cytokinin pathways.

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.

Newcastle disease virus induced ferroptosis through p53-SLC7A11-GPX4 axis mediated nutrient deprivation in tumor cells

This study shows that Newcastle disease virus induces ferroptosis in tumor cells via the p53-SLC7A11-GPX4 pathway, leading to nutrient deprivation and cell death.

Proteasomal degradation of human SERINC4: a potent host anti-HIV-1 factor that is antagonized by Nef

This paper identifies SERINC4 as a potent anti-HIV-1 host factor that is degraded by the proteasome and antagonized by Nef via the lysosomal pathway.

Momilactone B inhibits Arabidopsis growth and development via disruption of ABA and auxin signaling

Momilactone B inhibits Arabidopsis growth and development by disrupting ABA and auxin signaling, highlighting the role of phytohormones in allelopathic responses.

Electron microscopic observation of infected CCB and whole genome analysis of Koi herpesvirus isolate GY01

The paper describes electron microscopy of KHV GY01 infected cells and whole genome analysis to study its characteristics and phylogenetic relationships with other KHV strains.

Global Screening of Sentrin-Specific Protease Family Substrates in SUMOylation

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

Characterization of pyruvate dehydrogenase complex E1 alpha and beta subunits of Mycoplasma synoviae

This study characterizes the pyruvate dehydrogenase complex E1 alpha and beta subunits of Mycoplasma synoviae, showing their surface localization and binding to plasminogen and fibronectin, which contribute to adhesion.

Infectious bronchitis virus attaches to lipid rafts and enters cells via clathrin mediated endocytosis

This study identifies the molecular mechanisms of infectious bronchitis virus (IBV) entry, showing it attaches to lipid rafts and enters via clathrin-mediated endocytosis, followed by endosomal trafficking and membrane fusion.

CHOP and IRE1α-XBP1/JNK signaling promote Newcastle Disease Virus induced apoptosis and benefit virus proliferation

This study identifies CHOP and IRE1α-XBP1/JNK signaling as mediators of NDV-induced apoptosis and their role in promoting virus proliferation in tumor cells.