M. S. Fu

PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages, which are key infection reservoirs for Cryptococcus neoformans.

This study shows microglia support cryptococcal brain infections by hosting fungal growth and facilitating copper acquisition, and demonstrates that IFNγ can block this process.

This study identifies Cln1 as a regulator of G2 arrest and titan cell formation in Cryptococcus neoformans under stress conditions.

This study shows that prolonged exposure of Cryptococcus neoformans to amoebae leads to pleiotropic phenotypic and genetic changes that enhance resistance to predation and macrophage toxicity.

The paper shows macrophages use a bet-hedging strategy by stochastically acidifying phagolysosomes to reduce variation in antimicrobial effectiveness.

The paper investigates Cryptococcus neoformans transfer between macrophages, finding that it occurs via a non-lytic process involving exocytosis and phagocytosis, termed Dragotcytosis.

This study investigates the role of annexins in Cryptococcus neoformans, finding that the annexin gene is not essential for virulence or mating but affects titan cell formation.

This study shows that the capsule of Cryptococcus neoformans buffers phagosomal acidification, interfering with host defense mechanisms.

This study shows that Mg2+ and Ca2+ enhance A. castellanii's ability to kill C. neoformans by improving phagocytosis and adhesion.