Antibody escape and cryptic cross-domain stabilization in the SARS CoV-2 Omicron spike protein
K. Javanmardi, T. H. Segall-Shapiro, C.-W. Chou, D. R. Boutz, R. J. Olsen, X. Xie, H. Xia, P.-Y. Shi, C. D. Johnson, A. Annapareddy, S. Weaver, J. M. Musser, A. D. Ellington, I. J. Finkelstein, J. D. Gollihar
This study examines the molecular effects of Omicron spike mutations on ACE2 binding and antibody escape, revealing compensatory stabilizing mutations that enable high mutation counts.
bioRxiv · Apr 18, 2022Immunology