Author

A. D. Ellington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Annapareddy· 1 shared A. J. Simon· 1 shared A. Pothukuchy· 1 shared B. Alexander· 1 shared B. R. Morrow· 1 shared C. D. Johnson· 1 shared C. J. Zhu· 1 shared C. Jung· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperImmunology

A. Annapareddy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Antibody escape and cryptic cross-domain stabilization in the SARS CoV-2 Omicron spike protein

K. Javanmardi, T. H. Segall-Shapiro, C.-W. Chou, D. R. Boutz, R. J. Olsen, X. Xie, H. Xia, P.-Y. Shi, C. D. Johnson, A. Annapareddy, S. Weaver, J. M. Musser, A. D. Ellington, I. J. Finkelstein, J. D. Gollihar

This study examines the molecular effects of Omicron spike mutations on ACE2 binding and antibody escape, revealing compensatory stabilizing mutations that enable high mutation counts.

bioRxiv · Apr 18, 2022Immunology

Deep learning redesign of PETase for practical PET degrading applications

H. Lu, D. J. Diaz, N. J. Czarnecki, C. J. Zhu, W. Kim, D. J. Acosta, B. Alexander, R. Shroff, H. Cole, Y. J. Zhang, N. Lynd, A. D. Ellington, H. S. Alper

This paper uses deep learning to redesign PETase, creating a highly active and stable enzyme for efficient PET degradation and industrial recycling.

bioRxiv · Oct 10, 2021 · PreprintBioengineering

Supercharging enables organized assembly of synthetic biomolecules

A. J. Simon, V. Ramasubramani, J. Glaser, A. Pothukuchy, J. Gerberich, J. Leggere, B. R. Morrow, J. Golihar, C. Jung, S. C. Glotzer, D. W. Taylor, A. D. Ellington

The paper describes a method to assemble synthetic protein oligomers and higher-order structures using supercharged variants of fluorescent proteins, resulting in novel biomaterials.

bioRxiv · May 16, 2018Bioengineering