H. Xia

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

Riluzole reverses blood-testis barrier loss to rescue chemotherapy induced male infertility by binding to TRPC

This study shows riluzole restores blood-testis barrier function and rescues chemotherapy-induced male infertility in mice by targeting TRPC5.

A cross-species framework for investigating perceptual evidence accumulation

This paper develops a cross-species evidence accumulation task to compare perceptual decision-making in humans, rats, and mice, finding similar strategies but species-specific priorities in speed, accuracy, and reward optimization.

Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer

This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.

FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages

This study examines the replication and cross-neutralization of SARS-CoV-2 Omicron sublineages in mice and human airway cultures, finding distinct antigenic profiles and bivalent vaccine support.

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by 4 doses of parental mRNA vaccine or a BA.5-bivalent booster

This study evaluates the neutralization effectiveness of parental mRNA vaccines and BA.5-bivalent boosters against new SARS-CoV-2 variants, showing limited neutralization against BA.2.75.2, BQ.1.1, and XBB.1.

Global mosquito virome profiling and mosquito spatial diffusion pathways revealed by marker-viruses

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection

This study evaluates the neutralization of Omicron sublineages and Deltacron by BNT162b2 vaccine or BA.1 infection, finding BA.4/5 shows highest evasion.

Myeloid cell evolution uncovered by shrimp immune cell analysis at single-cell resolution

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

Antibody escape and cryptic cross-domain stabilization in the SARS CoV-2 Omicron spike protein

This study examines the molecular effects of Omicron spike mutations on ACE2 binding and antibody escape, revealing compensatory stabilizing mutations that enable high mutation counts.

Cross neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

The paper assesses cross-neutralization of Omicron BA.1 sera against BA.2, BA.3, and a pre-Omicron strain, finding reduced neutralizing titers against heterologous variants.

Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine

This study assesses the neutralization of Omicron sublineages BA.1, BA.2, and BA.3 by BNT162b2 vaccine sera, finding reduced neutralization compared to the original SARS-CoV-2 strain.

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

This paper describes a live-attenuated SARS-CoV-2 vaccine candidate with deleted ORFs that shows reduced replication and attenuation in animal models, and reports its protective efficacy against wild-type virus challenge.

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

Knockout of OsSWEET15 impaired rice embryo formation and seed-setting

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

Neutralization of Omicron SARS-CoV-2 by 2 or 3 doses of BNT162b2 vaccine

This study evaluates the neutralization of Omicron SARS-CoV-2 by two or three doses of the BNT162b2 vaccine, showing increased neutralization with three doses but reduced durability over time.

Collateral cleavage of 28s rRNA by RfxCas13d causes death of mice

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.

Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection

This study assesses cross-neutralization against Omicron SARS-CoV-2 from prior non-Omicron infections and finds significantly lower neutralization titers compared to the original strain.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

Inhibiting ACSL1 related ferroptosis restrains MHV-A59 infection

This study shows inhibiting ferroptosis reduces MHV-A59 infection by suppressing viral propagation and inflammation.

BNT162b2-Elicited Neutralization of Delta Plus, Lambda, and Other Variants

The paper assesses the neutralization ability of BNT162b2-elicited sera against SARS-CoV-2 variants, finding that all sera neutralize variants to titers of ≥80, indicating vaccine effectiveness against emerging strains.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

This study identifies the P681R mutation in the Delta variant's spike protein as critical for enhanced viral replication compared to the Alpha variant through increased furin cleavage of the spike protein.

Dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

Endothelial SIRPα signaling controls thymic progenitor homing for T cell regeneration and antitumor immunity

This study identifies endothelial SIRPα signaling as critical for thymic progenitor homing, T cell regeneration, and antitumor immunity through CD47-SIRP interactions and VE-cadherin endocytosis.

Neutralization of spike 69/70 deletion, E484K, and N501Y SARS-CoV-2 by BNT162b2 vaccine-elicited sera

The paper evaluates the neutralization effect of BNT162b2 vaccine-elicited sera against SARS-CoV-2 variants with specific spike mutations.