Phosphatidic acid inhibits SNARE priming by inducing conformational changes in Sec18 protomers
M. L. Starr, R. A. Sparks, L. R. Hurst, Z. Zhao, A. Arango, M. Lihan, J. L. Jenkins, E. Tajkhorshid, R. A. Fratti
This study shows phosphatidic acid (PA) inhibits SNARE priming by altering Sec18 conformation and stabilizing membrane-bound protomers.
bioRxiv · Jul 9, 2018Biochemistry