R. A. Fratti

The paper describes a high-throughput method to screen V-ATPase inhibitors/activators using Acridine Orange in yeast vacuoles.

This study shows that Ca2+ and H+ transport across the yeast vacuole membrane are reciprocally regulated and linked to Phosphatidylinositol 3,5-bisphosphate production.

This study shows that sphingolipids with very long-chain fatty acids regulate vacuole fusion by affecting membrane fluidity and Ypt7 function in yeast.

The paper investigates how a small molecule alters Sortilin's function, affecting ApoB and PCSK9 trafficking in liver cells and revealing a conserved mechanism in yeast.

This study shows that copper inhibits yeast vacuole fusion by blocking SNARE complex formation and V-ATPase activity, with Cu2+ being the active species.

This study shows that PI(3,5)P2 regulates Ca2+ transport in yeast vacuoles by activating Pmc1 during fusion, opposing its role in fission.

This study shows that PI(3,5)P2 inhibits yeast vacuole fusion after SNARE complex formation and during hemifusion, acting as a molecular switch between fission and fusion.

This study shows phosphatidic acid (PA) inhibits SNARE priming by altering Sec18 conformation and stabilizing membrane-bound protomers.