Z. Zhao

Bestrophin-4 relays Hes4 and interacts with Twist1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

This study identifies BEST4 as a tumor suppressor in colorectal cancer that interacts with Hes4 to inhibit EMT and metastasis.

QSAR Model Based Gradient Boosting Regression of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Inhibitors for Fructose-1,6-Bisphosphatase

This study develops a Gradient Boosting Regression model to predict the inhibitory activity of N-Arylsulfonyl-Indole-2-Carboxamide derivatives against Fructose-1,6-Bisphosphatase, achieving high correlation and statistical significance.

Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis

This study identifies TMEM68 as a triacylglycerol synthase that regulates lipid metabolism and membrane lipid composition in neuro- and glioblastoma cells.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Quantitative Superresolution Imaging of F-Actin in the Cell Body and Cytoskeletal Protrusions Using Phalloidin-Based Single-Molecule Labeling and Localization Microscopy

This paper introduces phalloidin-based single-molecule labeling and localization microscopy (SMLLM) for superresolution imaging of F-actin, showing improved quantification and structural preservation in dendritic cells.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

GhCPK28 negatively regulates the immune response by phosphorylating GhTIFY3b

This study identifies GhCPK28 as a negative regulator of cotton immunity against Verticillium dahliae by phosphorylating and destabilizing GhTIFY3b, enhancing resistance when silenced.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

Regulatory divergences in dosage compensation cause hybrid male inviability in Caenorhabditis

Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

Deciphering the co-evolutionary dynamics of L2 β-lactamases via Deep learning

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Quorum Sensing Positively Regulates CPS-dependent Autographiviridae Phages Infection in Vibrio alginolyticus

This study shows quorum sensing in V. alginolyticus increases CPS-dependent phage infection by upregulating ugd gene expression and CPS synthesis.

Detecting Features of Protein Structure through their Mediator-Accessible Redox Activities

This paper introduces an electronic detection method to identify structural perturbations in proteins by measuring mediator-accessible redox activities, demonstrating its application in biomanufacturing.

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

This study shows that inhibiting the integrated stress response (ISR) or PKR reduces vascular remodeling in PVOD models, suggesting potential therapeutic strategies.

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

Quality Control for Single Cell Analysis of High-plex Tissue Profiles using CyLinter

This paper introduces CyLinter, a quality control tool that removes imaging artefacts from high-plex spatial profiling data, improving single-cell analysis of archival tumor specimens.

Ex vivo structures from spinach leaves

The paper reports the structures of ten protein complexes from spinach leaves using a new ex vivo method that enables cryoEM-based high-resolution structure determination without genome manipulation or high-affinity binders.

Integrative pan-cancer analysis reveals a common architecture of dysregulated transcriptional networks characterized by loss of enhancer methylation

This study identifies common dysregulated transcriptional networks across cancers linked to loss of enhancer methylation through pan-cancer emQTL analysis.

Survey of white-footed mice in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses

The study surveys white-footed mice in Connecticut, finding low SARS-CoV-2 seroprevalence and identifying two divergent betacoronaviruses.

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β; pro-inflammatory signaling

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells

This study identifies HSPA8-mediated CLPP stability as a regulator of mitochondrial autophagy and cisplatin resistance in ovarian cancer cells.

The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability

This study identifies STUB1 as a tumor suppressor in ccRCC by promoting YTHDF1 degradation, with low STUB1 expression linked to poor patient outcomes.

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

Bacterial degradation of ctenophore Mnemiopsis leidyi organic matter

The paper investigates how bacterial communities respond to the degradation of ctenophore Mnemiopsis leidyi organic matter, finding similar patterns to those observed with jellyfish blooms.

Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

WBSCR16 Determines Metabolic Flexibility Via Regulating Mitochondrial 16S rRNA Maturation

This study identifies WBSCR16 as a key regulator of metabolic flexibility by controlling mitochondrial 16S rRNA maturation and switching between glucose and lipid metabolism.

Spatial redundancy transformer for self-supervised fluorescence image denoising

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.

Ferroptosis induced by phenolic compound-iron complex

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.