In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology
A. Ebenig, S. Muraleedharan, J. Kazmierski, D. Todt, A. Auste, M. Anzaghe, A. Gömer, D. Postmus, P. Gogesch, M. Niles, R. Plesker, C. Miskey, M. Gellhorn Serra, A. Breithaupt, C. Hörner, , M. D. Mühlebach
This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.
bioRxiv · Dec 28, 2021 · PreprintImmunology