DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces
S. Miron, P. Legrand, S. E. van Rossum-Fikkert, D. Ristic, A. Badar, R. Kanaar, S. Zinn-Justin, A. N. Zelensky
This paper explains how BRCA2's FxxA and FxPP motifs bind to DMC1 and RAD51 via distinct interfaces, stabilizing recombinase filaments and explaining functional differences between these proteins.
bioRxiv · Oct 5, 2023Biochemistry