N. Roy

Immunocompetent Cell Targeting by Food-Additive Titanium Dioxide

This study identifies immunocompetent cells that accumulate food-grade titanium dioxide in vivo and demonstrates a mouse model for assessing human-relevant risks of ingested nanoparticles.

A genetically-encoded nanobody sensor reveals conformational diversity in beta-arrestins orchestrated by distinct seven transmembrane receptors

This study introduces a nanobody sensor to detect conformational changes in beta-arrestins upon GPCR activation, revealing receptor-specific conformational diversity.

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

This study identifies CD97 as a targetable vulnerability in glioblastoma through its role in tumor metabolism and signaling, supported by transcriptomic, proteomic, and functional analyses.

Ancient genomic linkage couples metabolism with erythroid development

This study identifies Nprl3 as a key regulator of erythroid metabolism, showing its role in coupling metabolic and developmental processes during erythropoiesis.

Disease Resistance correlates with Core Microbiome Diversity in Cotton

The paper investigates the relationship between core microbiome diversity and disease resistance in cotton, finding an inverse correlation with disease susceptibility.

Cotton Microbiome Profiling and Cotton Leaf Curl Disease (CLCuD) Suppression through Microbial Consortia associated with Gossypium arboreum

The paper investigates the microbiome of CLCuD-resistant and susceptible cotton species to identify microbial consortia that suppress the disease and induce resistance.

Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions

This study shows Bacopa monnieri extract enhances fibroblast migration through focal adhesion modulation, improving wound healing.

In silico analysis of Bacopa monnieri (L.) Wettst. compounds for drug development against Neurodegenerative Disorders

This study uses in silico methods to evaluate phytochemicals from Bacopa monnieri as potential drug candidates for neurodegenerative disorders by analyzing their binding to neurotrophin receptors.

Individualized Gaussian Process-based Prediction of Memory Performance and Biomarker Status in Ageing and Alzheimer's disease

The paper uses Gaussian process multikernel modeling to predict memory performance and CSF biomarkers in ageing and Alzheimer's disease using MRI and other data.

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

This study identifies an allosteric cysteine in JAK1 and TYK2, develops inhibitors targeting it, and shows high subtype selectivity with minimal off-target effects.

Oxidised phosphatidylcholines induce multiple functional defects in airway epithelial cells

This study shows oxidized phosphatidylcholines (OxPC) impair airway epithelial cell function, causing barrier dysfunction, reduced proliferation, and oxidative stress, consistent with asthma pathology.

Development of an in vitro Experimental Model for Investigating the Effect of Matrix Stiffness on Epithelial Barrier Permeability

The paper develops an in vitro model to measure epithelial barrier permeability under varying substrate stiffness and shows that stiffness affects barrier function.