The aminoglycoside streptomycin triggers ferroptosis in tumor initiating cells
H. Guillorit, S. Relier, B. Zagiel, A. Di Giorgio, C. Cazevieille, L. Bansard, C. Bouclier, X. Mialhe, M. Brisset, S. Hideg, A. Choquet, C. Planque, A. Bastide, J. Pannequin, M. Duca, , A. David
This study shows that streptomycin induces ferroptosis in tumor initiating cells by altering mitochondrial morphology and ROS production, with its aldehyde group critical for this effect.
bioRxiv · Oct 31, 2022 · PreprintCancer Biology