FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
S. RELIER, J. RIPOLL, H. GUILLORIT, A. AMALRIC, F. BOISSIERE, J. VIALARET, A. ATTINA, F. DEBART, A. CHOQUET, F. MACARI, E. SAMALIN, J.-J. VASSEUR, J. PANNEQUIN, E. CRAPEZ, C. HIRTZ, , A. DAVID
This study shows FTO-mediated m6Am demethylation reduces CSC properties in colorectal cancer by affecting translation efficiency, not transcriptome remodeling.
Nature Communications · Mar 19, 2021Peer-reviewedCancer Biology