A. David

Translational control of cell plasticity drives 5-FU tolerance

The paper shows 5-FU induces translational reprogramming in colorectal cancer cells, enhancing drug tolerance through pro-tumoral gene expression and IL-8 overexpression.

How Myosin VI Traps its Off-State, is Activated and Dimerizes

This study investigates how Myosin VI is trapped in its off-state, activated, and dimerizes through structural and functional analyses of its interactions with partners.

Paracetamol/acetaminophen hepatotoxicity: new markers for monitoring the elimination of the reactive N-Acetyl-p-benzoquinone imine

The paper identifies thiomethyl metabolites as new markers to monitor NAPQI elimination after therapeutic use or intoxication.

Altered X-chromosome inactivation predisposes to autoimmunity

This study shows that altered X-chromosome inactivation in female mice leads to autoimmune features similar to lupus.

Paradox Found: Global Accounting of Lymphocyte Protein Synthesis

The paper measures protein synthesis rates in lymphocytes and finds that their in vivo elongation rates increase with activation, despite a high protein-to-ribosome ratio suggesting insufficient capacity for rapid division.

The aminoglycoside streptomycin triggers ferroptosis in tumor initiating cells

This study shows that streptomycin induces ferroptosis in tumor initiating cells by altering mitochondrial morphology and ROS production, with its aldehyde group critical for this effect.

In vitro modelling of oral microbial invasion in the human colon

This study develops an in vitro model to simulate oral microbial invasion of the human colon and finds that oral microorganisms preferentially colonize the mucosal compartment.

Biosynthesis of iridoid sex pheromones in aphids

This study identifies the biosynthetic pathway for iridoid sex pheromones in pea aphids, revealing an independently evolved pathway distinct from plants.

Comparing algorithms for assessing upper limb use with inertial measurement units

This study compares methods for assessing upper limb use with IMUs, finding that intra-subject random forest machine learning outperforms other approaches.

Encapsulated allografts preclude host sensitization and promote ovarian endocrine function in ovariectomized young rhesus monkeys and sensitized mice

This study shows that encapsulating ovarian allografts prevents immune sensitization and maintains endocrine function in both mice and rhesus monkeys.

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

This study shows FTO-mediated m6Am demethylation reduces CSC properties in colorectal cancer by affecting translation efficiency, not transcriptome remodeling.

A Framework for Sensor-based Assessment of Upper-limb Functioning

This paper introduces a framework for assessing upper-limb functioning using sensors, including definitions, visualization methods, and new quantitative measures.

Anti-apoptotic clone 11 derived peptides induce in vitro death of CD4+ T cells susceptible to HIV-1 infection

The paper shows that AAC-11-derived peptides induce death of HIV-1 susceptible CD4+ T cells by targeting metabolically active cells.

Optimal maturation of the SIV-specific CD8+ T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study

This study shows that optimal maturation of SIV-specific CD8+ T-cells correlates with natural control of SIV infection in macaques, with controllers developing more potent antiviral responses over time.

Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

This paper introduces Ribo-BiFC, a method to visualize ribosomes in Drosophila axons, revealing their distribution and activity in different neuronal compartments.

Reproducing Transformation of Indolent B-cell Lymphoma by T-cell Immunosuppression of L.CD40 Mice.

The paper shows that T-cell immunosuppression in L.CD40 mice transforms indolent B-cell lymphoma into an aggressive form, highlighting immune surveillance's role in disease progression.