In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer
Z. Chen, E. Arai, O. Khan, Z. Zhang, S. F. Ngiow, Y. He, H. Huang, S. Manne, Z. Cao, A. E. Baxter, Z. Cai, E. Freilich, M. A. Ali, J. R. Giles, J. E. Wu, , J. Shi
The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.
bioRxiv · May 20, 2020 · PreprintImmunology