Y. He

Equip Fusobacterium nucleatum genetic tool kits with compatible shuttle vectors and engineered intermediatory E. coli strains for enhanced transformation efficiency

This paper develops genetic tools for Fusobacterium nucleatum by engineering E. coli intermediates and shuttle vectors, achieving 5000 transformants per microgram plasmid.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

ClpP-dependent protein quality control supports antibiotic persistence in Campylobacter jejuni through bioenergetic homeostasis

This study identifies ClpP-dependent proteostasis as critical for antibiotic persistence in C. jejuni through bioenergetic homeostasis and metabolic remodeling.

Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by 'Candidatus Liberibacter asiaticus'

This study identifies adipokinetic hormone signaling as a key mediator of increased fecundity in CLas-infected D. citri, revealing a mutualistic interaction between the bacterium and the insect.

Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

This study shows ATG5 and membrane atg8ylation regulate retromer function in GLUT1 trafficking, independent of canonical autophagy.

Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

This study uses a protein language model to discover new phosphorus-cycling protein families in deep-sea cold seep sediments, revealing novel microbial processes and ecological roles.

Fluorogenic Aptamer Optimizations on a Massively Parallel Sequencing Platform

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

Structural insights into the in situ assembly of clustered protocadherin γB4

This study investigates the in situ assembly of cPcdh-γB4 using electron tomography, revealing distinct roles of ectodomain and intracellular domain in intermembrane organization.

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

This study integrates single-cell and bulk RNA-seq data to identify ferroptosis-related genes in TNBC, developing a risk score model to predict prognosis and guide drug selection.

TurboID-mediated surface protein biotinylation to inhibit the growth of Staphylococcus aureus

This study uses TurboID-mediated biotinylation of surface proteins to inhibit the growth and virulence of multiple S. aureus strains.

Evaluate the efficiency of Mr BMT in macrophage replacement of peripheral organs

This study evaluates Mr BMT's efficiency in replacing macrophages in peripheral organs, finding comparable replacement efficiencies to traditional BMT in liver, kidney, lung, and spleen.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

FKBP11 targeted plasma cells promote abdominal aortic aneurysm progression through an m6A-dependent mechanism

This study identifies FKBP11's role in AAA progression via m6A-dependent mechanisms using multi-omics and machine learning.

Aberration correction for deformable mirror based remote focusing enables high-accuracy whole-cell super-resolution imaging

This paper develops a deformable mirror-based remote focusing system to enable high-accuracy whole-cell super-resolution imaging with uniform resolution across thick samples.

Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.

This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2

This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.

Effects of arbuscular mycorrhizal fungi on nitrogen uptake in cotton (Gossypium hirsutum L.) under low-nitrogen conditions

This study examines how arbuscular mycorrhizal fungi affect nitrogen uptake in cotton under low-nitrogen conditions, finding increased root biomass and soil enzyme activity with AMF symbiosis.

Comparative transcriptomic and lipidomic analysis of fatty acid accumulation in three Camellia oleifera varieties during maturation

This study compares transcriptomic and lipidomic profiles of three Camellia oleifera varieties during seed maturation, linking fatty acid composition to gene expression patterns.

Protocatechuic acid induces endogenous oxidative stress in CR-hvKP by regulating the EMP-PPP pathway

This study shows that protocatechuic acid (PCA) enhances antibiotic efficacy against carbapenem-resistant hypervirulent Klebsiella pneumoniae by inducing oxidative stress through regulation of the EMP-PPP pathway.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

This study presents structural and biochemical analysis of E. coli FtsEX complex, revealing ATP's role in stabilization and EnvC-mediated activation of PG hydrolysis.

Arf GTPase-activating protein ASAP1 specifically binds to 440-kD ankyrin-B

The paper identifies ASAP1 as a specific binder of gAnkB, revealing structural and functional insights into their interaction and potential roles in axonal cytoskeleton regulation.

Standardized Parts for Activation of Small GTPase Signaling in Living Cells

This paper introduces a split-protein-based method to directly activate small GTPase signaling in living cells using standardized parts that work across the superfamily.

GTPase-activating protein ARAP1 regulates circular dorsal ruffles as a nutrient uptake mechanism in the Hep3B hepatocellular carcinoma cell line

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

Imaging spectroscopy reveals topographic variability effects on grassland functional traits and drought responses

This study uses high-resolution airborne imaging spectroscopy to analyze functional trait variation and drought responses across topographic gradients in a heterogeneous grassland.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.