Hepatic Leukemia Factor supports the propagation of leukemia and hematopoietic stem cell function during stress-induced regeneration.
A. Baudet, K. Komorowska, S. Hultmark, M. Chapellier, K. Miharada, J. Larsson, D. Bryder, M. Jaras, G. Juliusson, M. Magnusson
This study shows HLF is essential for stress-induced hematopoietic regeneration and leukemia propagation in aged HSCs but not for normal aging hematopoiesis.
bioRxiv · Mar 5, 2021 · PreprintCancer Biology