T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2
S. D. van Asten, R. d. Groot, M. M. van Loenen, J. d. Jong, K. Monkhorst, J. B. Haanen, D. Amsen, A. Bex, R. M. Spaapen, M. C. Wolkers
The paper examines TILs from RCC patients, finding that while some are tumor-reactive, they fail to produce key cytokines in response to autologous tumors.
bioRxiv · May 17, 2020 · PreprintImmunology