Author

K. Monkhorst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Assay:flow cytometry· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Guislain· 3 shared M. C. Wolkers· 3 shared R. de Groot· 3 shared D. Amsen· 2 shared J. B. Haanen· 2 shared K. J. Hartemink· 2 shared M. M. van Loenen· 2 shared R. M. Spaapen· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

A. Guislain

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products

S. M. Castenmiller, N. Kanagasabesan, A. Guislain, B. Nicolet, M. van Loenen, K. Monkhorst, A. Veenhof, E. Smit, K. Hartemink, J. Haanen, R. de Groot, M. Wolkers

This study identifies that high B cell infiltrates in NSCLC tumors, associated with tertiary lymphoid structures, negatively correlate with the tumor-reactivity of expanded TIL products.

bioRxiv · Feb 19, 2024Immunology

Effective generation of tumor-infiltrating lymphocyte products from metastatic non-small-cell lung cancer (NSCLC) lesions irrespective of location and previous treatments.

S. M. Castenmiller, R. de Groot, A. Guislain, K. Monkhorst, K. J. Hartemink, A. A. F. A. Veenhof, E. F. Smit, J. B. A. G. Haanen, M. C. Wolkers

This study shows that tumor-infiltrating lymphocytes (TILs) can be effectively generated from metastatic NSCLC lesions regardless of location or prior treatments, with 76% showing anti-tumoral activity.

bioRxiv · Jan 28, 2022Cancer Biology

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2

S. D. van Asten, R. d. Groot, M. M. van Loenen, J. d. Jong, K. Monkhorst, J. B. Haanen, D. Amsen, A. Bex, R. M. Spaapen, M. C. Wolkers

The paper examines TILs from RCC patients, finding that while some are tumor-reactive, they fail to produce key cytokines in response to autologous tumors.

bioRxiv · May 17, 2020 · PreprintImmunology

Glucocorticoids regulate cancer cell dormancy

S. Prekovic, K. Schuurman, A. Gonzalez Manjon, M. Buijs, I. Mayayo Peralta, M. D. Wellenstein, S. Yavuz, A. Barrera, K. Monkhorst, A. Huber, B. Morris, C. Lieftink, J. Silva, B. Györffy, L. Hoekman, , W. Zwart

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.

bioRxiv · Sep 4, 2019 · PreprintCancer Biology

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

R. de Groot, M. M. van Loenen, A. Guislain, B. P. Nicolet, J. J. Freen-van Heeren, O. Verhagen, M. M. van den Heuvel, J. de Jong, P. Burger, E. van der Schoot, R. M. Spaapen, D. Amsen, J. B. Haanen, K. Monkhorst, K. J. Hartemink, M. C. Wolkers

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.

bioRxiv · Jun 8, 2019Immunology