Author

A. Biddle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Scemama· 2 shared G. Youssef· 2 shared H. Cottom· 2 shared I. C. Mackenzie· 2 shared L. Ambler· 2 shared L. Gammon· 2 shared M. P. Philpott· 2 shared S. Lunetto· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

A. Scemama

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Author profile →

4 papers

Recent·Most cited

A tug-of-war between the NuRD and SWI/SNF chromatin remodelers regulates the coordinated activation of Epithelial-Mesenchymal Transition and inflammation in oral cancer.

R. Stabile, F. A. Tucci, M. P. Verhagen, C. Embregts, T. P. P. Van denBosh, R. Joosten, M. J. de HErdt, B. van der Steen, A. L. Nigg, S. Koljenovic, J. A. Hardillo, C. P. Verrijzer, A. Biddle, R. J. Baatenburg de Jong, P. J. Leenen, R. Fodde

The paper shows that competition between NuRD and SWI/SNF chromatin remodelers regulates epithelial-mesenchymal plasticity and inflammation in oral cancer, with CDK2AP1 loss promoting pro-inflammatory responses and macrophage recruitment.

bioRxiv · Apr 5, 2024 · PreprintCancer Biology

Hybrid cancer stem cells utilise vascular tracks for collective streaming invasion in a metastasis-on-a-chip device

A. Scemama, S. Lunetto, A. Tailor, S. Di Cio, L. Ambler, A. Coetzee, H. Cottom, S. A. Khurram, J. Gautrot, A. Biddle

This study shows hybrid cancer stem cells use vascular tracks for collective invasion in a metastasis-on-a-chip model of oral squamous cell carcinoma.

bioRxiv · Jan 2, 2024 · PreprintCancer Biology

A CD24+CD271+ Melanoma Cancer Stem Cell Possesses Hybrid Characteristics of its Single Marker Counterparts and Promotes Invasion and Therapeutic Resistance

O. Knowles, P. Doldan, I. Hillier-Richardson, S. Lunt, G. Youssef, L. Gammon, I. C. Mackenzie, M. P. Philpott, H. Rizvi, D. Bergamaschi, C. A. Harwood, A. Biddle

The paper identifies a CD24+CD271+ melanoma sub-population with hybrid characteristics and enhanced invasive and therapeutic resistance properties.

bioRxiv · Jun 7, 2023Cancer Biology

Disseminating cells in human tumours acquire an EMT cancer stem cell state that is predictive of metastasis

G. Youssef, L. Gammon, L. Ambler, S. Lunetto, A. Scemama, H. Cottom, K. Piper, I. C. Mackenzie, M. P. Philpott, A. Biddle

The paper identifies disseminating EMT cancer stem cells in human oral cancer specimens using EpCAM, CD24, and Vimentin markers, which predict metastasis with high accuracy.

bioRxiv · Apr 7, 2020Cancer Biology