Author

R. Joosten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. van der Steen· 3 shared R. Fodde· 3 shared A. Perrakis· 2 shared A. Sacchetti· 2 shared M. P. Verhagen· 2 shared R. Stabile· 2 shared T. Heidebrecht· 2 shared A. Adamopoulos· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

B. van der Steen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A tug-of-war between the NuRD and SWI/SNF chromatin remodelers regulates the coordinated activation of Epithelial-Mesenchymal Transition and inflammation in oral cancer.

R. Stabile, F. A. Tucci, M. P. Verhagen, C. Embregts, T. P. P. Van denBosh, R. Joosten, M. J. de HErdt, B. van der Steen, A. L. Nigg, S. Koljenovic, J. A. Hardillo, C. P. Verrijzer, A. Biddle, R. J. Baatenburg de Jong, P. J. Leenen, R. Fodde

The paper shows that competition between NuRD and SWI/SNF chromatin remodelers regulates epithelial-mesenchymal plasticity and inflammation in oral cancer, with CDK2AP1 loss promoting pro-inflammatory responses and macrophage recruitment.

bioRxiv · Apr 5, 2024 · PreprintCancer Biology

The origin of intestinal cancer in the context of inflammation

M. P. Verhagen, R. Joosten, M. Schmitt, N. Valimaki, A. Sacchetti, K. Rajamaki, J. Choi, P. Procopio, S. Silva, B. van der Steen, T. P. P. van den Bosch, D. Seinstra, M. Doukas, L. H. Augenlicht, L. A. Aaltonen, R. Fodde

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Distant sequence regions of JBP1 contribute to J-DNA binding

I. de Vries, D. Ammerlaan, T. Heidebrecht, P. Celie, D. Geerke, R. Joosten, A. Perrakis

The paper investigates how JBP1's JDBD binds to J-DNA using crystal structures, MD simulations, and mutagenesis, revealing the role of the N-terminus in DNA binding.

bioRxiv · Jan 23, 2023Biochemistry

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

A. Sacchetti, M. Teeuwssen, M. Verhagen, R. Joosten, T. Xu, R. Stabile, B. van der Steen, M. M. Watson, A. Gusinac, W. K. Kim, I. Ubink, H. J. van de Werken, A. Fumagalli, M. Paauwe, J. van Rheenen, , R. Fodde

This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.

bioRxiv · Jul 24, 2020Cancer Biology

Characterisation and structure determination of a llama-derived nanobody targeting the J-base binding protein 1

B. van Beusekom, T. Heidebrecht, A. Adamopoulos, A. Fish, E. Pardon, J. Steyaert, R. Joosten, A. Perrakis

The paper characterizes a llama-derived nanobody targeting JBP1, showing high affinity and solving its crystal structure to 1.64 Å resolution, with insights into CDR flexibility.

bioRxiv · Jun 7, 2018Biochemistry