Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells
E. M. Ensink, T. Jordan, H. C. Dias de Medeiros, G. Thurston, A. Pardal, L. Yu, S. Lunt
This study shows that PKM2 knockout in pancreatic cancer cells increases resistance to cystine starvation-induced ferroptosis by reprogramming glutamine metabolism through ME1 to produce NADPH.
bioRxiv · Sep 15, 2023 · PreprintCancer Biology