P. Doldan

A CD24+CD271+ Melanoma Cancer Stem Cell Possesses Hybrid Characteristics of its Single Marker Counterparts and Promotes Invasion and Therapeutic Resistance

The paper identifies a CD24+CD271+ melanoma sub-population with hybrid characteristics and enhanced invasive and therapeutic resistance properties.

Population context drives cell-to-cell variability in interferon response in epithelial cells

The paper shows that population context affects cell-to-cell variability in interferon response in human intestinal epithelial cells, with edge cells being more responsive than central ones.

Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection

This study identifies host cell master regulators affected by SARS-CoV-2 and develops a method to find drugs that reverse their inactivation without harming beneficial immune responses.

Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells

This study shows that type III interferons are more effective than type I interferons in reducing SARS-CoV-2 infection in human intestinal epithelial cells.

Host Cell Proteases Drive Early or Late SARS-CoV-2 Penetration

This study investigates how SARS-CoV-2 uses different host cell proteases for entry, showing that TMPRSS2 enables rapid entry while cathepsin L and low pH are required in its absence.

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut

This study identifies enterocytes as the main target of SARS-CoV-2 in the gut and shows the virus suppresses interferon signaling to evade immune response.