Structural Basis for Membrane Recruitment of ATG16L1 by WIPI2 in Autophagy
L. M. Strong, C. Chang, A. Boecker, T. G. Flower, C. Z. Buffalo, X. Ren, A. K. Stavoe, E. L. F. Holzbaur, J. H. Hurley
This study determines the crystal structure of WIPI2 interacting with ATG16L1, revealing the molecular mechanism of ATG16L1 recruitment to the phagophore and its role in autophagy initiation.
bioRxiv · May 14, 2021Cell Biology