X. Ren

An immunoediting map of human cancers

The paper constructs an immunoediting map of human cancers by analyzing single-cell data from 11057 tumor samples and 17382 healthy samples, revealing common immune cell state changes across cancer types.

Fluid flow reconstruction around a free-swimming sperm in 3D

This study reconstructs fluid flow around a free-swimming human sperm using 3D microscopy and numerical models, revealing counter-rotating vortices in the flow pattern.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Beyond enumeration: Phenotype independent "labeling-capture-release" process enabling precise detection of circulating tumour cells and downstream applications

This paper introduces a labeling-capture-release method for isolating circulating tumor cells from blood samples with high efficiency and accuracy, enabling downstream applications.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

A 'shock-and-lock' nanoparticle agonist activates STING in type 1 conventional dendritic cells to enhance antitumor immunity with associated biomarkers.

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification

This study identifies impaired myofibroblast proliferation as a central feature of alveolar simplification in BPD using single-cell RNA sequencing and pharmacologic approaches.

Exploration of the intricacies of low light-induced changes in cigar tobacco leaf anticlinal growth: A holistic approach from anatomical and hormonal levels to gene expression

This study examines how low light affects cigar tobacco leaf morphology, growth rates, and gene expression, revealing hormonal and cellular changes in leaf structure.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

Transcriptional coupling of telomeric retrotransposons with the cell cycle

This study identifies Mediator complex subunits, Scalloped, and E2F1-Dp as regulators of telomeric retrotransposon transcription and telomere length in Drosophila, linking TR expression to the cell cycle.

Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

Genetic synergy in Acinetobacter baumannii undecaprenyl biosynthesis and maintenance of lipid asymmetry impacts outer membrane and antibiotic resistance

The paper identifies a SNP in uppS that synergizes with mlaF deletion to increase susceptibility to membrane stress and antibiotics in A. baumannii.

Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore

The paper identifies three sequential steps by which the ATG12-ATG5-ATG16L1 complex delivers LC3 to the phagophore via WIPI2, ATG16L1, and ATG3.

Swimming by spinning: spinning-top type rotations regularize sperm swimming into persistently symmetric paths in 3D

This paper investigates how sperm swimming paths become symmetric through spinning-top type rotations despite asymmetric flagellar beating, revealing that orientation, not path, indicates beat symmetry.

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

The paper determines the cryo-EM structure of the human ULK1C core and its complex with PI3KC3-C1, revealing structural changes that suggest a mechanism for autophagy initiation through supercomplex formation.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Membrane and glycocalyx tethering of DNA nanostructures for enhanced uptake

This study enhances DNA nanostructure cellular uptake by targeting membrane and glycocalyx, showing improved uptake and endocytic pathways involving scavenger receptors and clathrin/caveolin mechanisms.

Synthetic cell armor made of DNA origami

This paper develops a DNA origami nanoshell to protect cells from mechanical stress by enhancing membrane stiffness and reducing lipid fluidity, improving cell viability.

Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation

This study reveals the scaffold-client model of PRC1 condensate assembly through phase separation, showing how CBX2 acts as a scaffold and other subunits influence condensate properties and composition.

A novel method revealing animal evolutionary relationships based on milk Mid-infrared

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

The paper determines the structure of ATG9A's C-terminal tail interacting with the ULK1 complex's ATG13:ATG101 HORMA dimer, revealing how this interaction facilitates mitophagy.

Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer

This study integrates multi-omic and phenotypic data to predict therapeutic response in leukemia and ovarian cancer, identifying biomarker profiles and mechanisms of resistance.

Metabolomics and transcriptomics reveal the response mechanisms of Mikania micrantha to Puccinia spegazzinii infection

This study investigates how Mikania micrantha responds to Puccinia spegazzinii infection using metabolomics and transcriptomics, identifying changes in metabolites and gene expression.

Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat

The paper determines the structure of an AP-1:Arf1 tubular membrane coat formed without clathrin, revealing its self-assembly mechanism and role in HIV-1 immune evasion.

Super-resolution vibrational imaging using expansion stimulated Raman scattering microscopy

The paper introduces MAGNIFIERS, a technique combining SRS microscopy with expansion microscopy to achieve sub-50 nm resolution and scalable multiplexity for label-free chemical imaging.

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

Exploring the Neoantigen burden in Breast Carcinoma Patients

This study analyzes neoantigen burden in breast cancer patients using whole-exome and RNA sequencing, finding high patient-specificity and correlation with somatic mutations.

NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.